2010
DOI: 10.1089/acm.2009.0267
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Concurrent Use of Corticosteroids with Licorice-Containing TCM Preparations in Taiwan: A National Health Insurance Database Study

Abstract: Potential risk of corticosteroid-licorice interactions may happen, even through formal medical services. In the future, such educational propagations should be reinforced. Furthermore, an alert device that includes well-recognized drug-herb interactions should be built into every hospital's computer system to remind physicians to be cautious on drug safety.

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Cited by 12 publications
(8 citation statements)
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References 31 publications
(33 reference statements)
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“…1). GA has been shown to have anti-inflammatory effects in different systems through multiple mechanisms, such as inhibitory effects on reactive oxygen species (ROS) overproduction and NF-κB pathway activation [6,7]. However, little is known about the role of GA in the immunological regulation during viral infection.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…1). GA has been shown to have anti-inflammatory effects in different systems through multiple mechanisms, such as inhibitory effects on reactive oxygen species (ROS) overproduction and NF-κB pathway activation [6,7]. However, little is known about the role of GA in the immunological regulation during viral infection.…”
Section: Introductionmentioning
confidence: 99%
“…HMGB1 also functions as an extracellular signaling molecule during inflammation, cell differentiation, cell migration, and tumor metastasis [9]. GL has been reported to interact with a motif within HMGB1 and inhibit its chemoattractant and mitogenic activities [6,10]. Additionally, GA can also bind selectively to HMGB1 protein and inhibit its cytokine activities by preventing accumulation of HMGB1 protein [11].…”
Section: Introductionmentioning
confidence: 99%
“…Glycyrrhizin (GL; Figure 1) is an active compound isolated from the root of licorice (Glycyrrhiza glabra; Glycyrrhiza radix; Chinese name: Gancao). In traditional Chinese medicine, licorice is one of the most commonly used herbs in treating liver disorders [27]. It is also used to reduce toxicity, to improve appetite and enhance the effectiveness of other ingredients in prescriptions [27,28].…”
Section: Introductionmentioning
confidence: 99%
“…In traditional Chinese medicine, licorice is one of the most commonly used herbs in treating liver disorders [27]. It is also used to reduce toxicity, to improve appetite and enhance the effectiveness of other ingredients in prescriptions [27,28]. There is evidence for the therapeutic application of glycyrrhizin for chronic hepatitis induced by viral infections, toxin exposure and ischemic-reperfusion injury [29].…”
Section: Introductionmentioning
confidence: 99%
“…Typical clinical presentation of HDI include the potentiation of the effects of oral corticosteroids in the presence of liquorice ( Glycyrrhiza glabra ; Liao et al, 2010); potentiation of warfarin effects with resultant bleeding in the presence of garlic ( Allium sativum ; Borrelli et al, 2007), dong quai ( Angelica sinensis ; Nutescu et al, 2006), or danshen ( Salvia miltiorrhiza ; Chan, 2001); decreased blood levels of nevirapine, amitriptyline, nifedipine, statins, digoxin, theophylline, cyclosporine, midazolam, and steroids in patients concurrently consuming St John’s wort (SJW; Hypericum perforatum ; De Maat et al, 2001; Henderson et al, 2002; Johne et al, 2002; Mannel, 2004; Borrelli and Izzo, 2009), decreased oral bioavailability of prednisolone in the presence of the Chinese herbal product xiao-chai-hu tang (sho-saiko-to; Fugh-Berman, 2000); ginseng ( Panax ginseng )-induced mania in patients on antidepressants (Engelberg et al, 2001); production of extrapyramidal effects as a result of the combination of neuroleptic drugs with betel nut ( Areca catechu ; Huang et al, 2003; Coppola and Mondola, 2012); increased blood pressure induced by tricyclic antidepressant-yohimbe ( Pausinystalia yohimbe ) combination (Tam et al, 2001), increased phenytoin clearance and frequent seizures when combined with Ayurvedic syrup shankhapushpi (Patsalos and Perucca, 2003), among other clinical manifestations. These clinical presentations depend on the mechanism of HDI.…”
Section: Resultsmentioning
confidence: 99%