Concurrent Use of Cocaine and Alcohol by Patients Treated in the Emergency Department

Vanek, Vincent W.; Dickey-White, Howard; Signs, Steven A.; Schechter, Martin; Buss, Terry F.; Kulics, Albert T.

doi:10.1016/s0196-0644(96)70114-2

Cited by 36 publications

(27 citation statements)

References 16 publications

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“…Some retrospective studies that have looked at human drug users to investigate the effect of alcohol/cocaine combinations on violence provided evidence suggesting that violence and agitation are attributable more to the use of alcohol than cocaine 43-45. Although findings from two studies suggest that there is a synergistic effect of alcohol and cocaine combination on violent behavior, the data are difficult to interpret due to lack of appropriate control groups 46,47…”

Section: Discussionmentioning

confidence: 99%

Transient Cocaine-Associated Behavioral Symptoms Rated with a New Instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)

Tang¹,

Kranzler²,

Gelernter³

et al. 2009

Am J Addict

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Chronic use of cocaine is associated with a variety of behavioral symptoms. The current report describes the assessment of cocaine-related behavioral symptoms (CRB) using the Scale for Assessment of Positive Symptoms of Cocaine-Induced Psychosis (SAPS-CIP). The CRB section, one of the three domains in the SAPS-CIP, consists of sub-domains, including Aggressive/Agitated Behavior, Repetitive/Stereotyped Behavior, Unusual Social or Sexual Behavior. Severity scores are assigned according to operational criteria, and range from 0 (not present) to 5 (severe). We interviewed 261 unrelated cocaine-abusing adults using the SAPS-CIP, and 243 of them met criteria for inclusion in the study. The proportion of subjects endorsing different classes of CRBs varied across categories, with 109 of 243 (44.9%) subjects reporting aggressive and agitated behaviors, 180 subjects (74.1%) repetitive/stereotyped behaviors, and 192 (79.0%) unusual social/sexual behaviors. A substantial minority of the subjects (10.3-25.1%) reported that they experienced marked-to-severe behavioral symptoms associated with cocaine use. The proportions of subjects endorsing CRB did not differ by ethnic/racial group or by sex. Correlations among the different domains of CRB were strong, but behaviors rated in the CRB section were less well correlated with psychotic symptoms, which were rated in the hallucination and delusion sections of the instrument. A variety of CRBs are common in cocaine-dependent subjects, and many of these are highly intercorrelated. CRBs also correlate with hallucinations and delusions induced by cocaine, but to a lesser degree. Our findings suggest that there may be some common vulnerability factors that contribute to both cocaine-induced psychosis and CRBs.

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Section: Discussionmentioning

confidence: 99%

Transient Cocaine-Associated Behavioral Symptoms Rated with a New Instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)

Tang¹,

Kranzler²,

Gelernter³

et al. 2009

Am J Addict

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“…These data support the idea that cocaine use could increase the vulnerability to the development of ethanol dependence (Rubio et al, 2008) and vice versa. A careful examination of the clinical data indicates that the concurrent use of ethanol and cocaine is associated with increased mortality and morbidity resulting from cerebro-and cardiovascular complications (Cami et al, 1998;O'Connor et al, 2005;Randall, 1992;Vroegop et al, 2009) as well as hepatotoxicity and compromised mental status (Odeleye et al, 1993;Vanek et al, 1996). Taken together, these facts underscore the urgency and necessity to develop pharmacotherapeutic interventions for alcoholism and the comorbidity of alcoholism with cocaine use.…”

Section: Introductionmentioning

confidence: 99%

Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: The effects on immediate-early gene expression in the rat prefrontal cortex

et al. 2012

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“…The prevalence of concurrent abuse and dependence of cocaine and alcohol is a serious public health problem associated with significant morbidity and mortality as well as high cost of health care (Coffin et al, 2003; Grant & Harford, 1990; McCance-Katz, Kosten, & Jatlow, 1998; Vanek et al, 1996). Concurrent use has been associated with mental health disorders, other drug use and adverse social consequences.…”

Section: Introductionmentioning

confidence: 99%

Differences between adult non-drug users versus alcohol, cocaine and concurrent alcohol and cocaine problem users

Hedden

Malcolm

Latimer

2009

Addictive Behaviors

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Concurrent drug use is a serious public health concern with significant morbidity and mortality associated with the combined use of alcohol and cocaine. Multinomial logistic regression was used to assess differences between non-drug users and alcohol, cocaine and concurrent problem users incorporating data from the 2005 National Survey on Drug Use and Health. Results demonstrated that alcohol and cocaine use is associated with mental health disturbance, other drug use and adverse social consequences. Furthermore, concurrent users were more likely to report cigarette and marijuana use as well as lifetime STDs and arrest for breaking the law. Study results have implications for planning prevention and treatment services differentially for alcohol, cocaine and concurrent users and support the need for more intense resources allocated to the prevention and treatment of the concurrent use of alcohol and cocaine.

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Concurrent Use of Cocaine and Alcohol by Patients Treated in the Emergency Department

Cited by 36 publications

References 16 publications

Transient Cocaine-Associated Behavioral Symptoms Rated with a New Instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)

Transient Cocaine-Associated Behavioral Symptoms Rated with a New Instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)

Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: The effects on immediate-early gene expression in the rat prefrontal cortex

Differences between adult non-drug users versus alcohol, cocaine and concurrent alcohol and cocaine problem users

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