Concurrent spinal cord and vertebral bone marrow radionecrosis 8 years after therapeutic irradiation

Abstract

Concurrent radionecrosis within the spinal cord and the bone marrow at the same thoracic level was observed 8 years after localized therapeutic irradiation in a patient who had undergone repeated cycles of radiotherapy, glucocorticoid treatment, and chemotherapy for a non-Hodgkin's lymphoma. Mechanisms combining radiotoxic potentialization by glucocorticoids/alkylating agents and delayed radiation-induced vasculitis involving the common arterial pathways to the spinal cord and to the vertebrae were speculated to have acted in a synergistic way.

Ewingʼs Sarcoma of the Mobile Spine

“…4,6,21 The risk of local recurrence is probably lower for patients treated with an en bloc surgical excision with adequate margins. [31][32][33] The risk of local recurrence is probably higher with an intralesional excision compared with en bloc spondylectomy. The role of an intralesional excision combined with radiation therapy for patients with ES of the spine is unclear.…”

Perianale Radionekrose 17 Jahre nach perkutaner Radiotherapie wegen eines Ovarialkarzinoms und nach wiederholten Probeexzisionen

“…Eine Radionekrose von Knochen oder Haut ist insbesondere nach Strahlentherapie von Kopf-und Halstumoren [2], aber auch nach Strahlentherapie bei Mamma- [3], Spinal- [4], Penis- [5], Uterus-/Zervixtumoren [6], Weichteiltumoren an Gliedmaßen [7] und anderen gynäkologischen Tumoren [8][9][10][11] beschrieben worden. Insgesamt konnten bei der Literaturrecherche nur drei Publikationen gefunden werden, in denen eine Radionekrose der Perianalhaut [12][13][14] beschrieben wird.…”

Consequences of Radiation Accidents

“…For this reason, late radiation effects of radiotherapy are well-known for various tissues and organs, [1][2][3][4][5][6][7][8][9] and skin necrosis as late as 22 years has been reported. 10 However, the medical literature is clearly devoid of studies and compilations regarding the effects of ionized radiation accidents.…”