Concurrent radiation and chemotherapy for carcinoma of the cervix recurrent after radical surgery

The prognosis in women with locally advanced primary or recurrent gynecologic malignancies is rather poor. Doses of external beam radiation necessary to treat gross or microscopic recurrence among patients surgically treated or previously irradiated exceed what is tolerated by normal structures. In this group of patients, intraoperative radiation therapy (IORT) can be utilized to maximize local tumor control, minimizing the radiation exposure of dose-limiting surrounding structures. Review of the available literature indicates that IORT may improve long-term local control and overall survival in women with pelvic sidewall and/or para-aortic nodal recurrence. The most encouraging results have been reported in the cases of microscopic residual disease, following surgical debulking. The

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“…Most authors cite a five-year survival rate of ≤5% among patients with pelvic recurrences of cervical cancer [9].…”

Section: Recurrent Diseasementioning

confidence: 99%

The Role of Intraoperative Radiation Therapy (IORT) in the Treatment of Locally Advanced Gynecologic Malignancies

Carmen¹,

McIntyre

Goodman³

2000

The Oncologist

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“…The search for relevant studies did not identify any RCTs but 16 case series met the inclusion criteria: nine evaluated radiotherapy [84][85][86][87][88][89][90][91][92] and seven evaluated chemoradiotherapy. [93][94][95][96][97][98][99] The results of the quality assessment for the radiotherapy and chemoradiotherapy studies are presented in Appendix 15.…”

Section: Study Selectionmentioning

confidence: 99%

“…Seven studies [93][94][95][96][97][98][99] were identified and their baseline patient characteristics are provided in Table 45. Most included a small number of patients (median 30 cases, range 13-49 cases).…”

Section: Population Characteristicsmentioning

confidence: 99%

“…The majority of women presented with earlystage cervical cancer. In three studies 93,94,97 there were no data on FIGO stage. In each of the studies the proportion of patients with disease recurrent or persistence in the pelvis as the only site of cancer (central recurrence) was lower than the proportion developing distant metastases.…”

Section: Population Characteristicsmentioning

confidence: 99%

“…The best-quality RCT found compared cisplatin with no cisplatin with both groups receiving radiotherapy, 127 which gave an overall 5-year survival with cisplatin of 63% and without cisplatin of 59%. Only case series were found on radiotherapy (nine studies [84][85][86][87][88][89][90][91][92] ), chemoradiotherapy (seven studies [93][94][95][96][97][98][99] ), radical hysterectomy (seven studies [100][101][102][103][104][105][106] ) and pelvic exenteration (20 studies [107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] ). The survival rates varied considerably, depending on the date of publication, characteristics of patients and type of treatment given.…”

Section: Effectiveness Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Positron emission tomography/computerised tomography imaging in detecting and managing recurrent cervical cancer: systematic review of evidence, elicitation of subjective probabilities and economic modelling

Meads

Auguste²,

Davenport³

et al. 2013

Health Technol Assess

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Reports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others.

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Iodine-125 interstitial implants as salvage therapy for recurrent gynecologic malignancies

Sharma

Forgione

Isaacs

1991

Cancer

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Twenty-one patients with the diagnosis of recurrent gynecologic pelvic malignancy from various primary sites were treated with iodine-125 (I-125) interstitial implants. Eighteen of these patients had been treated with a combination of surgery and radiation therapy for their primary malignancies and 90% had responded. Seventy-five percent had complete local responses. The overall survival time, volume-response relationship, and complications are discussed and the radioresponse of various histologic types is presented.

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Concurrent radiation and chemotherapy for carcinoma of the cervix recurrent after radical surgery

Cited by 35 publications

References 8 publications

The Role of Intraoperative Radiation Therapy (IORT) in the Treatment of Locally Advanced Gynecologic Malignancies

The Role of Intraoperative Radiation Therapy (IORT) in the Treatment of Locally Advanced Gynecologic Malignancies

Positron emission tomography/computerised tomography imaging in detecting and managing recurrent cervical cancer: systematic review of evidence, elicitation of subjective probabilities and economic modelling

Iodine-125 interstitial implants as salvage therapy for recurrent gynecologic malignancies

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