Concurrent pulmonary tuberculosis and primary carcinoma

Berroya, Renato B.; Polk, John W.; Raju, P. Suvarna; Bailey, Alan

doi:10.1136/thx.26.4.384

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…Sixteen case‐control studies were eventually used for the estimation of TB prevalence in lung cancer patients . All studies reported findings concerning cases of active pulmonary TB complicating lung cancer, verified with biopsy and bacteriological examination.…”

Section: Resultsmentioning

confidence: 99%

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Epidemiology of active tuberculosis in lung cancer patients: a systematic review

Christopoulos¹,

Saif

Sarris

et al. 2014

Clinical Respiratory J

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Objectives: The aim of this review article is to evaluate the available literature concerning the prevalence of active tuberculosis in lung cancer patients. Data Source: MEDLINE, PubMed, EMBASE and Medscape databases were searched for studies with quantitative data on the interaction between tuberculosis (TB) and lung cancer, published since 1952. We used the Medical Subject Headings' term 'tuberculosis' and the text-word terms 'TB' and 'Mycobacterium infection' , and also, the Medical Subject Headings' terms 'neoplasm' and 'lung neoplasm' , or the text-word term 'lung cancer' . Data Selection: We selected studies with cases verified by bacteriological examinations and biopsies that contained enough data to estimate tuberculosis prevalence. We did not exclude any study on the basis of language. Results: The prevalence of active tuberculosis among lung cancer patients varies depending on spatial and regional factors. Lung cancer patients who are more prone to developing tuberculosis are Asian and Caucasian males, with an average age of 60 years old. The prevalence of tuberculosis is higher in patients with chest X-ray evidence of old tuberculosis and/or history of tuberculosis, chronic obstructive pulmonary disease, heavy cigarette smoking, increased alcohol consumption, and/or diabetes mellitus. A high mortality rate because of tuberculosis in lung cancer patients was also estimated. Conclusion: Active tuberculosis complicating lung cancer is a significant clinical issue in countries with high prevalence of tuberculosis. However, as the there is a lack of reports from developed countries over the last 20 years, the significance of this interaction in countries with low tuberculosis burden remains controversial.Please cite this paper as: Christopoulos A, Saif MW, Sarris EG and Syrigos KN. Epidemiology of active tuberculosis in lung cancer patients: a systematic review. Clin Respir J 2014; 8: 375-381.

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Section: Resultsmentioning

confidence: 99%

“…With regard to the histological subtypes of lung cancer most commonly associated with TB, the results are conflicting; nine studies have shown a predominance of squamous cell carcinoma, while three studies have demonstrated a closer association of pulmonary TB with adenocarcinoma.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of active tuberculosis in lung cancer patients: a systematic review

Christopoulos¹,

Saif

Sarris

et al. 2014

Clinical Respiratory J

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“…(15). They insisted that the sudden appearance of new lesions, segmental or lobar atelectasis, unilateral hilar enlargement, thick-walled cavities, and a localized pneumonic process are all suggestive of carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

et al. 2001

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ObjectiveBronchogenic Carcinoma Can Mimic Or Be Masked By Pulmonary Tuberculosis (Tb), And The Aim Of This Study Was To Describe The Radiologic Findings And Clinical Significance Of Bronchogenic Carcinoma And Pulmonary Tb Which Coexist In The Same Lobe.Materials and MethodsThe findings of 51 patients (48 males and three females, aged 48-79 years) in whom pulmonary TB and bronchogenic carcinoma coexisted in the same lobe were analyzed. The morphologic characteristics of a tumor, such as its diameter and margin, the presence of calcification or cavitation, and mediastinal lymphadenopathy, as seen at CT, were retrospectively assessed, and the clinical stage of the lung cancer was also determined. Using the serial chest radiographs available for 21 patients, the possible causes of delay in the diagnosis of lung cancer were analyzed.ResultsLung cancers with coexisting pulmonary TB were located predominantly in the upper lobes (82.4%). The mean diameter of the mass was 5.3 cm, and most tumors (n=42, 82.4%) had a lobulated border. Calcification within the tumor was seen in 20 patients (39.2%), and cavitation in five (9.8%). Forty-two (82.4%) had mediastinal lymphadenopathy, and more than half the tumors (60.8%) were at an advanced stage [IIIB (n=11) or IV (n=20)]. The average delay in diagnosing lung cancer was 11.7 (range, 1-24) months, and the causes of this were failure to observe new nodules masked by coexisting stable TB lesions (n=8), misinterpretation of new lesions as aggravation of TB (n=5), misinterpretation of lung cancer as tuberculoma at initial radiography (n=4), masking of the nodule by an active TB lesion (n=3), and subtleness of the lesion (n=1).ConclusionMost cancers concurrent with TB are large, lobulated masses with mediastinal lymphadenopathy, indicating that the morphologic characteristics of lung cancer with coexisting pulmonary TB are similar to those of lung cancer without TB. The diagnosis of lung cancer is delayed mainly because of masking by a tuberculous lesion, and this suggests that in patients in whom a predominant or growing nodule is present and who show little improvement of symptoms despite antituberculous or other medical therapy, coexisting cancer should be suspected.

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“…The prognosis of patients with lung cancer and TB is considered poor because more than half of them have advanced malignant disease at presentation . Previous reports suggest that rapid development of new lesions, segmental or lobar atelectasis, unilateral hilar enlargement, thick‐walled cavities, and a localised pneumonic process indicate coexistent lung cancer and TB .…”

Section: Discussionmentioning

confidence: 99%

Carcinomatous pleuritis and pericarditis accompanied by pulmonary tuberculosis

Hara

Iwakami

Matsumoto

et al. 2016

Respirology Case Reports

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Although both lung cancer and pulmonary tuberculosis (TB) commonly occur in clinical practice, little attention has been paid to their coexistence. A 62-year-old female was admitted with acute dyspnoea secondary to cardiac tamponade. During her admission, a mass lesion harbouring air bronchograms in the right upper lobe rapidly increased in size. Surgical lung, pericardial, and pleural specimens yielded TB from a nodule in the right upper lobe and lung adenocarcinoma from the pericardium and pleura. Anti-tuberculous therapy was administered and gefitinib was subsequently started after the positive identification of epidermal growth factor receptor (EGFR) mutation (exon 19 deletion). The patient's general condition gradually improved with the anti-tuberculous and the EGFR-tyrosine kinase inhibitor (EGFR-TKI) treatment. Dual pathology is important to consider in patients with atypical radiological appearances. In those with proven EGFR mutation positive for lung cancer and pulmonary TB, sequential anti-tuberculous medication followed by EGFR-TKI treatment is advised.

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Concurrent pulmonary tuberculosis and primary carcinoma

Cited by 12 publications

References 23 publications

Epidemiology of active tuberculosis in lung cancer patients: a systematic review

Epidemiology of active tuberculosis in lung cancer patients: a systematic review

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

Carcinomatous pleuritis and pericarditis accompanied by pulmonary tuberculosis

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