Concurrent photothermal therapy and photodynamic therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser irradiation

Liu, Pei; Yang, Wenjun; Shi, Lei; Zhang, Haiyan; Xu, Yan; Wang, Peiru; Zhang, Guolong; Chen, Wei R.; Zhang, Bingbo; Wang, Xiuli

doi:10.1039/c9tb01573f

Cited by 98 publications

(67 citation statements)

References 58 publications

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“…Namely, the antioxidant NAC completely abolished the proapoptotic effects of indirubins, restored cell viability and cell proliferation as well as prevented all other effects induced by indirubins. ROS production was also reported for other cSCC therapies, such as for chemotherapy, photothermal therapy [59] and photodynamic therapy [60,61].…”

Section: Discussionmentioning

confidence: 69%

Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells

et al. 2021

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Efficient drugs are needed for countering the worldwide high incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis. Indirubin derivatives represent promising candidates, but their effects in cSCC cells have not been reported before. Here, we investigated the efficacy of three indirubin derivatives (DKP-071, -073 and -184) in four cSCC cell lines. High efficacy was seen in SCL-I, SCL-II, SCC-12 and SCC-13, resulting in up to 80% loss of cell proliferation, 60% loss of cell viability and 30% induced apoptosis (10 µM). Apoptosis was further enhanced in combinations with TNF-related apoptosis-inducing ligand (TRAIL). Induction of reactive oxygen species (ROS) appeared as critical for these effects. Thus, antioxidative pretreatment completely abolished apoptosis as well as restored cell proliferation and viability. Concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic PKCδ (protein kinase C delta), inhibition of STAT3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic XIAP (X-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic Bcl-2 protein Puma and the cell cycle inhibitor p21 were obtained. Importantly, all activation steps were prevented by antioxidants, thus proving ROS as a master regulator of indirubins’ antitumor effects. ROS induction presently develops as an important issue in anticancer therapy.

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Section: Discussionmentioning

confidence: 69%

Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells

et al. 2021

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“…Together with the high photothermal conversion efficiency and strong photothermal stability, gold nanoclusters are promising to deliver the integrated PTT and PDT using single‐laser irradiation. [ 102 ]…”

Section: Multifunctional Gold Nanomaterials For Combinatorial Phototherapymentioning

confidence: 99%

The Golden Age: Shining the Light on Theragnostics

Yang

Wang

2021

Advanced NanoBiomed Research

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Gold nanoparticles have attracted unprecedented attention as one of the leading nanomaterials in the field of biomedicine. Of particular interest are their inherent and geometrically tunable optical properties upon the interaction with light, facilitating breakthroughs in light‐mediated diagnosis and therapeutics. Herein, an up‐to‐date overview of the current research in utilizing versatile gold‐based nanosystems with distinctive optical features for optical imaging and phototherapy is provided. The recent advances in optical biosensing, surface‐enhanced Raman scattering‐based detection, photoacoustic imaging, optical coherence tomography, photothermal therapy, light‐triggered drug release, photodynamic therapy, and optomodulation of neural functions using the novel and elegant gold nanostructures of unique design are summarized. In recognition of the burgeoning popularity of integrating multiple diagnostic and therapeutic functions in one system, recent developments of various multifunctional gold nanoplatforms for the light‐enabled concomitant diagnosis and therapy are also highlighted. In the end, the current limitations and perspectives in clinical translation of gold nanomaterial‐assisted photodiagnosis and phototherapy are discussed along with the concluding remarks.

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“…Nevertheless, recent studies are quite misleading about the application of PTT and PDT, which rely on different therapeutic mechanisms. However, when ICG is used, both effects could be achieved although with a distinct tumor cell–killing contribution by each (Liu et al, 2019a ). More clarity about which strategy is being referred to is necessary since, through ICG, one thing does not exclude the other, and the related side effects should be considered as well.…”

Section: Icg-nps: Opportunities Limitations and Possible Impacts In mentioning

confidence: 99%

Indocyanine Green Nanoparticles: Are They Compelling for Cancer Treatment?

et al. 2020

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Indocyanine green (ICG) is a Food and Drug Administration-approved near-infrared fluorescent dye, employed as an imaging agent for different clinical applications due to its attractive physicochemical properties, high sensitivity, and safety. However, free ICG suffers from some drawbacks, such as relatively short circulation half-life, concentration-dependent aggregation, and rapid clearance from the body, which would confine its feasible application in oncology. Here, we aim to discuss encapsulation of ICG within a nanoparticle formulation as a strategy to overcome some of its current limitations and to enlarge its possible applications in cancer diagnosis and treatment. Our purpose is to provide a short but exhaustive overview of clinical outcomes that these nanocomposites would provide, discussing opportunities, limitations, and possible impacts with regard to the main clinical needs in oncology.

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Concurrent photothermal therapy and photodynamic therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser irradiation

Abstract: The concurrent photothermal and photodynamic therapy of cutaneous squamous cell carcinoma by a single drug of Au25(Capt)18 nanoclusters is demonstrated, together with a preliminary immune response study conducted under a single NIR laser irradiation.

Cited by 98 publications

References 58 publications

Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells

Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells

The Golden Age: Shining the Light on Theragnostics

Indocyanine Green Nanoparticles: Are They Compelling for Cancer Treatment?

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