Concurrent Medullary, Papillary, and Follicular Thyroid Carcinomas and Simultaneous Cushing's Syndrome

Abstract

Background: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5-8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid gland are extremely rare and reported scarcely. Case Report: A 72-year-old male presented with nonspecific neck pain. The workup revealed a nodular thyroid gland with a follicular lesion on fine-needle aspiration. Total thyroidectomy was performed and pathological examination identified a 25-mm follicular carcinoma, two papillary microcarcinomas, and two medullary microcarcinomas. The genetic workup was negative and no other family members were diagnosed with any endocrinopathy. Two months after surgery, the patient was diagnosed with Cushing's syndrome that was treated with laparoscopic left adrenalectomy. On 3-year follow-up, the patient is asymptomatic with no evidence of recurrent disease. Conclusion: We present a rare case of a patient with follicular, papillary, and medullary thyroid carcinoma, and Cushing's syndrome. To date, no known genetic mutation or syndrome can account for this combination of neoplastic thyroid and adrenal pathologies, although future research may prove differently.

Optical biopsy of head and neck cancer using hyperspectral imaging and convolutional neural networks

“…However, the co-occurrence of both MTC and PTC is rare, although cases have been documented. [38][39][40] We hypothesized that HSI has further potential than binary cancer detection, as we explored in this work, and that different types of cancer can be identified from benign hyperplasia. Therefore, we performed a set of two binary classifications (MTC versus MNG and PTC versus MNG) to show both can be successfully identified from MNG.…”

A Rare Encounter – Papillary Thyroid Cancer Meets Cushing’s Disease Case report and literature review

“…Mazeh reported a case of concurrent papillary, medullary, follicular thyroid carcinoma with adrenal Cushing's syndrome which was tested for RET mutations which were not found [22].…”

Preoperative Diagnosis predicts Outcomes in Patients with Concurrent Medullary and Papillary Thyroid Carcinoma

“…Most of the available literature on patients with MTC and PTC are case reports without data on long-term outcomes. [1][2][3]7,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Consequently, there is little data available to clinicians about how to predict which tumor subtype will be most at risk for recurrence.…”