Concurrent loss of ciliary genesWDR93andCFAP46in phylogenetically distant birds
Salve Buddhabhushan Girish,
Amia Miriam Kurian,
Nagarjun Vijay
Abstract:The respiratory system is the primary route of infection for many contagious pathogens. Mucociliary clearance of inhaled pathogens is an important innate defense mechanism sustained by the rhythmic movement of epithelial cilia. To counter host defenses, viral pathogens target epithelial cells and cilia. For instance, the influenza virus modulates the expression of WDR93, a central ciliary apparatus C1d projection component. Lineage-specific prevalence of such host defense genes results in differential suscepti… Show more
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