Concurrent Kimura disease and lupus nephritis

Wang, Haitao; Fang, Fang; Sun, Ying; Wang, Songlan; Mao, Yonghui

doi:10.1097/md.0000000000005086

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…[ 21 ] In terms of pathological types, we found two kinds of kidney diseases: minimal change glomerulopathy and mesangial proliferative glomerulonephritis, while other types of renal diseases have been described in KD including membranous nephropathy, lupus nephritis, IgA and IgM nephropathy. [ 6 22 23 ] In this study, we found elevated serum IgE and blood basophils, and delay of the mass resection may be responsible for renal involvement. We also found that KD patients, especially those with renal involvement, often showed elevated blood CD4+ and CD8+ T cell counts and CD4+ to CD8+ T cell ratio.…”

Section: Discussionmentioning

confidence: 57%

Risk of Nephritis and Recurrence in Kimura Disease: A Retrospective Study

Zhang,

Chen,

Hui

et al. 2023

Indian Journal of Dermatology

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Background: Kimura disease (KD) presents a diagnostic challenge to clinicians because of its rarity and atypical symptoms in its early stages, and it is difficult to treat and prone to recurrence or involvement of other organs. Aims and Objectives: This study aims to investigate the possible relevance of renal involvement and recurrence by analysing the clinical presentations, laboratory results, histopathological features, therapeutic data and follow-up results of KD. Materials and Methods: A total of 27 patients diagnosed as KD in two hospitals from January 1999 to December 2021 were analysed retrospectively in this study based on the diagnosis of histopathology. Results: KD mainly affected male more than female (8:1) with the onset age ranging from 3 to 58 years (median 29.8 years). The common initial symptoms included subcutaneous soft tissue or lymph node enlargement, non-specific skin lesions and proteinuria. One patient presented cough and expectoration as the first symptoms. KD patients often had high levels of serum immunoglobulin E (IgE) and basophils, which exhibited a significantly positive correlation with renal involvement and recurrence (p < 0.05). Early mass resection could prevent the development of nephritis and decrease the risk of relapse (p < 0.05). Conclusion: KD should be noted in patients presenting with intractable and relapsing atopic skin lesions and (or) subcutaneous mass. Patients with high levels of serum IgE and blood basophils may be prone to developing KD-associated nephritis and predict a high risk of recurrence. Early surgical removal of the mass may result in a better prognosis.

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Section: Discussionmentioning

confidence: 57%

Risk of Nephritis and Recurrence in Kimura Disease: A Retrospective Study

Zhang,

Chen,

Hui

et al. 2023

Indian Journal of Dermatology

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“…Recently the co-presence of an increasing number of autoimmune diseases with KD has been reported. Wang et al [ 5 ] reported a case of KD concomitant with lupus nephritis in a 72-year-old male patient. Ben-Chetrit et al [ 4 ] described a family in which three siblings suffered from Behcet's disease and an additional brother suffered from KD.…”

Section: Discussionmentioning

confidence: 99%

Kimura's disease and ankylosing spondylitis

Chen

Cui

et al. 2020

Medicine

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Rationale: Ankylosing spondylitis (AS) and Kimura's disease (KD) which is quite rare are both chronic inflammatory diseases. Recently we encountered a patient who suffered from KD and AS, and some of his family members also suffer from AS. We, therefore, investigated this unique case and conducted the family-based whole exome sequencing to explore the possible genetic alterations. Patient concerns: Here, we reported a case of a 44-year-old Chinese man with multiple painless masses all over his body and a back pain for 32 years. His uncle and sister were diagnosed with AS. Diagnosis: The diagnosis of KD was based on the patient's clinical features and the biopsy of the neck masses. The diagnosis of AS was based on the patient's clinical features, HLA-B27(+) and the radiologic changes of sacroiliac joints. The genetic test showed that ARPC1B gene which was associated with recurrent infections, auto-inflammatory changes and elevated IgE levels was mutated in this patient. Interventions: Neck masses were removed by surgery. Systemic glucocorticoid, nonsteroidal anti-inflammatory agents, combined with cyclosporine were orally administered, and Etanercept was injected subcutaneously. Outcomes: The masses disappeared rapidly after surgery combined with systemic glucocorticoid, but relapsed shortly after the therapy was discontinued. Low dose glucocorticoid, cyclosporine and Etanercept could keep both KD and AS remained long-term remission. Lessons: Our experience suggests that low dose glucocorticoid, cyclosporine and Etanercept could be beneficial for the patient with KD and AS. The mutation of ARPC1B gene in this case, which is associated with immunologic disturbance, may increase the susceptibility of KD.

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“…[ 39 ] 1 2014 Chinese Male 53 1.7 × 1.1 × 1.1 neck surgical excision no 1.01 × 10 9 / L 537.2 recurrent / 68 Hsu, S. N. [ 40 ] 1 2015 Chinese Male 33 / head, lower extremity (edema) surgical excision, PTA, Cilostazol 50 mg, Pentoxifylline 400 mg, prednisolone 1 mg/kg/day, Cetirizine 5 mg twice a day no 34 to 51% 12,400-17,200 recurrent / not clear Ye, X. [ 41 ] 1 2015 Chinese Male 47 5 in diameter cervical, subaxillary and inguinal region prednisone 0.5 mg/kg/day, thalidomide 50 mg/day no 26.11% 1081.34 recurrent tapering of prednisolone 36 Wang, H. [ 42 ] 1 2016 Chinese Male 72 / head surgical excision, Chinese herbal remedies, cetirizine hydrochloride and olmesartan 20 mg/day, gamma immunoglobulin 10 g/day for 5 days, intravenous pulse methylprednisolone therapy 500 mg for 3 days, hydroxychloroquine 0.4 g/day, prednisone 50 mg/day, a single dose of intravenous cyclophosphamide 500 mg yes 35% 149,000 recurrent / 43 Matsuo, T. [ 11 ] 1 2017 Japanese Male 42 / head surgical excision, prednisone 40 mg/day, cyclosporine 75 mg/day yes 9.40% 735 recurrent tapering of prednisolone 82 Chakraborti, C. [ ...…”

Section: Discussionmentioning

confidence: 99%

Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

2020

BMC Surg

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Background Kimura’s disease is a rare, benign chronic inflammatory disease of unknown etiology that mostly affects Asians. The disease typically presents as subcutaneous masses in the head or neck region that are predominantly found in the preauricular and submandibular areas. Case presentation A 7-year-old boy presenting with paralysis of both lower extremities and a thoracic spine dumbbell mass was initially diagnosed with a neurogenic tumor, but the pathological and laboratory examinations confirmed the diagnosis of Kimura’s disease. The paralysis symptom disappeared rapidly, but the patient had developed a recurrent mass in the cervical vertebral canal at the 9-month follow-up. Conclusion To our knowledge, no prior published literature has revealed Kimura’s disease cases that mimic dumbbell neurogenic tumors. Here, we report such a case of Kimura’s disease for the first time and provide a brief review of the literature.

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Concurrent Kimura disease and lupus nephritis

Cited by 4 publications

References 24 publications

Risk of Nephritis and Recurrence in Kimura Disease: A Retrospective Study

Risk of Nephritis and Recurrence in Kimura Disease: A Retrospective Study

Kimura's disease and ankylosing spondylitis

Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

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