Background: Gastrointestinal stromal tumor (GIST) is the most common stromal tumor of the gastrointestinal tract and it is considered to be an aggressive tumor with potentially malignant tendency. GIST is a tumor derived from mesenchymal tissue of the gastrointestinal tract or rarely of intraperitoneal soft tissue. Stem cajal cells from the muscular layer of the digestive tract are the precursor cells of GIST, which are pacemaker cells that cause the intestinal peristalsis and contract. The etiology of GIST is mainly caused by mutations in the KIT or PDGFRA oncogene. Although some papers reported that inflammation can cause tumor formation, it has not been reported that inflammation can cause GIST formation.Case presentation: A 64-year-old male patient was evaluated for recurrent dull pain and discomfort in the left upper abdomen. He had a history of abdominal trauma approximately six years prior. During this period, abdominal pain and fever were intermittent recurrent attacked. Intraoperative jejunum tumors were found to have inflammatory packages. Postoperative pathological examinations showed that the tumor envelope was intact and a large amount of inflammatory cells were seen around the tumor cells. Histopathology of the resected masses was positive for CD117 and Dog-1, and the patient was diagnosed as jejunum GIST.Conclusion: We reported a case of gastrointestinal stromal tumor that may be caused by repeated stimulation of chronic inflammation that caused by trauma. Early detection and timely removal of the inducement of repeated chronic inflammation can effectively prevent the occurrence of GIST.