Concurrent infection with Theileria buffeli caused depression of parasitaemia in Babesia bovis and Anaplasma centrale infections in splenectomised calves but not in B bigemina infections

Stewart, N. P.; Vos, A.J. De; Standfast, N. F.

doi:10.1016/0034-5288(90)90071-b

Cited by 7 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may involve the stimulation of the production of tumor necrosis factor (TNF) and toxic reactive nitrogen and/or oxygen intermediates by monocytes, as has been shown for immunity against the intraerythrocytic stages of malaria (reviewed by Good and Miller 1989). This proposed non-specific effector mechanism is consistent with the observed non-specific immunity against A. marginale conferred by bacille CalmetteGuérin (BCG) vaccination (Sharma 1988) or concurrent Theileria infection (Stewart et al 1990;Gale et al, manuscript in preparation). We demonstrated high levels of IFN-γ in PBLPR-assay supernatants from day 4 to day 8 and subsequently analysed day-8 supernatants in further experiments.…”

Section: Discussionsupporting

confidence: 65%

“…Non-specific resistance is induced against A. centrale and A. marginale by concurrent infection with the immunologically unrelated, benign haemoprotozoan parasite Theileria buffeli (syn. T. orientalis; Stewart et al 1990;Gale et al, manuscript in preparation). In addition, non-specific immunity against A. marginale infection has been induced by treatment of cattle with mycobacterial preparations (Sharma 1988).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral blood lymphocyte proliferative responses in cattle infected with or vaccinated against Anaplasma marginale

Gale¹,

Gartside

Dimmock³

et al. 1996

Parasitol Res

View full text Add to dashboard Cite

An assay was developed for measurement of the peripheral blood lymphocyte proliferative response (PBLPR) in cattle infected with or immunised against Anaplasma marginale. PBLPR was not evident in all cattle that had recovered from A. marginale infection. However, A. marginale-sensitised lymphocytes were detected in the spleens of all immune cattle tested in the absence of detectable PBLPR. During the course of initial infection, cattle exhibited detectable PBLPR for a period corresponding with and up to 2 weeks after patent parasitaemia, followed by a second, usually larger peak in PBLPR corresponding to the time of sub-clinical relapse of cattle. Analysis of the PBLPR of A. marginale chronically infected cattle demonstrated highly variable PBLPR between individuals and over time. A positive PBLPR was induced in cattle by vaccination using a crude A. marginale antigen preparation. The PBLPR of vaccinated cattle subsequently infected with A. marginale was markedly different from that of naive cattle, with reduced PBLPR being associated with the onset of parasitaemia. The antigen used in the PBLPR assay was inactivated by proteolysis. Proteolysis also abolished immunity that had been induced in cattle vaccinated using the antigen preparation. A marginale-sensitised PBL did not proliferate in response to antigen from the heterologous species A. centrale. A. centrale-sensitised PBL, however, responded to A. marginale antigen. Interferon-gamma (IFN-gamma) was detected in PBLPR-assay supernatants and was associated with a strong PBLPR.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Peripheral blood lymphocyte proliferative responses in cattle infected with or vaccinated against Anaplasma marginale

Gale¹,

Gartside

Dimmock³

et al. 1996

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…The use of premunity has a long history in early "vaccinations" against Leishmania, malaria, East Coast fever, babesiosis and poultry coccidiosis ("precocious strains") see [96,97]. In Australia, pre-existing infections with T. orientalis buffeli actually suppressed infections with B. bovis and Anaplasma marginale but not B. bigemina in SPLx calves [98] and could do so for T. orientalis Ikeda in an experimental trial [47].…”

Section: Ipm To Produce Resistant Hosts: Immunisation Against Infectionmentioning

confidence: 99%

Approaches to Integrated Parasite Management (IPM) for Theileria orientalis with an Emphasis on Immunity

Emery

2021

Pathogens

View full text Add to dashboard Cite

Integrated parasite management (IPM) for pests, pathogens and parasites involves reducing or breaking transmission to reduce the impact of infection or infestation. For Theileria orientalis, the critical impact of infection is the first wave of parasitaemia from the virulent genotypes, Ikeda and Chitose, associated with the sequelae from the development of anaemia. Therefore, current control measures for T. orientalis advocate excluding the movement of naïve stock from non-endemic regions into infected areas and controlling the tick Haemaphysalislongicornis, the final host. In Australia, treatment of established infection is limited to supportive therapy. To update and expand these options, this review examines progress towards prevention and therapy for T. orientalis, which are key elements for inclusion in IPM measures to control this parasite.

show abstract

“…Non-specific immunity against A. marginale and the closely related species A. centrale has been observed in cattle chronically infected with the immunologically unrelated benign haemoprotozoan parasite Theileria orientalis (syn. T. buffeli, Stewart et al 1990, Gale et al 1997). In addition, the spleen plays a central role in immunity against anaplasmosis (Roby et al 1961) and lymphoproliferative responses have been demonstrated in the spleens of A. marginale-immune cattle (Gale et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Anaplasma marginale: effect of the treatment of cattle with an interferon γ‐neutralizing monoclonal antibody or the nitric oxide synthetase inhibitor aminoguanidine on the course of infection

Gale

Leatch

Dimmock

et al. 1997

Parasite Immunology

View full text Add to dashboard Cite

Cattle undergoing initial infection with the rickettsia Anaplasma marginale were treated with either a monoclonal antibody (MoAb) with neutralizing activity for bovine interferon gamma (IFN-gamma) or aminoguanidine (AG), a specific inhibitor of the inducible form of nitric oxide synthetase (iNOS). Plasma levels of MoAb and AG were measured over the time of administration. The course of A. marginale infection was not altered in the MoAb-treated cattle relative to untreated controls. In cattle treated with AG however, A. marginale infection was significantly ameliorated, as judged by lower parasite levels and decreased anaemia in these cattle relative to the controls. The implications of these findings in relation to the basis for immunity against this economically important haemoparasite are discussed.

show abstract

Concurrent infection with Theileria buffeli caused depression of parasitaemia in Babesia bovis and Anaplasma centrale infections in splenectomised calves but not in B bigemina infections

Cited by 7 publications

References 11 publications

Peripheral blood lymphocyte proliferative responses in cattle infected with or vaccinated against Anaplasma marginale

Peripheral blood lymphocyte proliferative responses in cattle infected with or vaccinated against Anaplasma marginale

Approaches to Integrated Parasite Management (IPM) for Theileria orientalis with an Emphasis on Immunity

Anaplasma marginale: effect of the treatment of cattle with an interferon γ‐neutralizing monoclonal antibody or the nitric oxide synthetase inhibitor aminoguanidine on the course of infection

Contact Info

Product

Resources

About