Concurrent FSGS and Hodgkin's lymphoma: case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies

Mallouk, Abdalla; Pham, Phuong‐Thu T.; Pham, Phuong‐Chi T.

doi:10.1007/s10157-006-0437-4

Cited by 68 publications

(57 citation statements)

References 27 publications

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“…In malignant diseases, causes of ARF include renal vascular compression, dehydration, nephrotoxic or ischemic acute tubular necrosis, hypercalcemia, urinary tract obstruction, paraproteinemia or glomerulonephropathy (especially MGN), or malignant cellular infiltration to the renal parenchyma, which is very rarely seen (10). While renal involvement is especially MGN in cases with solid tumor, minimal change disease is a frequent lesion in HL (20).…”

Section: Discussionmentioning

confidence: 99%

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A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

et al. 2011

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Although acute renal failure developing due to malignancies is a frequent condition, malignant renal infiltration is rarely observed among these causes. Among all malignant diseases, the hematolymphoid malignancies are the most prone to renal infiltration. Other types involved in cases with lymphoma are glomerulopathies, including immune-complex glomerular diseases such as minimal change disease, membranous glomerulonephritis, membranoproliferative glomerulonephritis, and focal segmental glomerulosclerosis. We present herein the rare case of a 22-year-old male with both membranous glomerulonephritis and CD20 (+) lymphoid infiltration related to Hodgkin's lymphoma in the renal interstitial tissue, as detected on biopsy. The patient was treated with adriamycin, bleomycin, vinblastine, and dacarbazine protocol after pulse corticosteroid treatment, and a dramatic improvement in renal function was observed after 2 days of treatment. In this article, an exceptional renal involvement of Hodgkin's lymphoma is discussed in light of the related literature.

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Section: Discussionmentioning

confidence: 99%

“…However, the encountered lesion is minimal change disease in approximately half of the cases (Table 1). 20 In this report, a case with ARF developing secondary to HL is discussed. This patient had MGN findings as well as malignant renal infiltration related to HL.…”

Section: Introductionmentioning

confidence: 99%

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

et al. 2011

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“…However, the true prevalence of cancer in patients with MN remains unknown and has been variously estimated as ranging between 5 and 22% [4,5,6,7,8,9]. Traditionally, the solid organ cancers most commonly associated with MN have been lung and gastrointestinal cancers [10], whereas MN associated with hematologic malignancy has been considered a rare entity [11]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Cancer in Membranous Nephropathy: A Systematic Review and Meta-Analysis of Observational Studies

Leeaphorn¹,

Kue-A-Pai²,

Thamcharoen³

et al. 2014

Am J Nephrol

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Background: The association between membranous nephropathy (MN) and cancer has been well documented. However, the true prevalence and characteristics of cancer associated with MN have not been well described. Methods: A systematic review and meta-analysis of cohort studies was conducted to summarize the prevalence of cancer-associated MN as well as patient characteristics and types of cancer in this population. We used a random-effects meta-analysis model to estimate the prevalence of cancer. Results: We included 6 studies (n = 785). The estimated prevalence of cancer was 10.0% (95% CI, 6.1-14.6). The mean age of MN patients with cancer was 67 ± 7 years. The diagnosis of cancer preceded the diagnosis of MN in 20 ± 6.8%. Lung cancer was the most common type of tumor, accounting for 22 cases (26%), followed by prostate cancer (13 cases, 15%), hematologic malignancies (12 cases, 14%), colorectal cancer (9 cases, 11%), breast cancer (6 cases, 7%), and stomach and esophageal cancer (5 cases, 6%). Conclusion: The estimated prevalence of cancer in patients with MN is 10% (95% CI, 6.1-14.6). The vast majority of tumors associated with MN are lung and prostate cancer. Hematologic malignancies should also be considered as one of the potential cancers associated with MN. Our study was based on a largely Caucasian population; therefore, the findings might not be applicable to other populations.

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“…Similarly, a monoclonal gammopathy in CLL can cause renal disease. 119,121 However, this is not due to an autoimmune mechanism, but rather to direct damage to renal tubules caused by deposition of immunoglobulins, particularly free light chains.…”

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confidence: 99%

Chronic lymphocytic leukemia and autoimmunity: a systematic review

Hodgson¹,

Ferrer²,

Montserrat³

et al. 2011

Haematologica

120

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Concurrent FSGS and Hodgkin's lymphoma: case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies

Cited by 68 publications

References 27 publications

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

Prevalence of Cancer in Membranous Nephropathy: A Systematic Review and Meta-Analysis of Observational Studies

Chronic lymphocytic leukemia and autoimmunity: a systematic review

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