Concurrent dietary intake to nitrate, thiocyanate, and perchlorate is negatively associated with hypertension in adults in the USA

Dietary Nitrate from Plant Foods: A Conditionally Essential Nutrient for Cardiovascular Health

“…Other relevant confounding factors affecting NOS-dependent and -independent pathways include antiseptic mouthwash use, thiocyanates from cruciferous vegetables, cyanide from cigarette smoke, sulfate in drinking water, and dietary lipid consumption. Although antiseptic mouthwash disrupts the oral microbiome necessary for nitrate reduction [ 47 , 119 , 120 ], thiocyanate, sulfate, and cyanide can decrease nitrate concentration in the saliva by blocking salivary ion transporters (for example, natrium-iodide symporter, chloride channel, and sialin) involved in nitrate uptake from blood [ [121] , [122] , [123] , [124] ]. Finally, dietary lipids can increase NO auto-oxidation in plasma, thereby decreasing its bioavailability [ 35 , 125 ].…”