Concurrent determination of olanzapine, risperidone and 9‐hydroxyrisperidone in human plasma by ultra performance liquid chromatography with diode array detection method: application to pharmacokinetic study

Kumar, Maushmi S.; Ramanathan, Madhumati

doi:10.1002/bmc.3545

Cited by 10 publications

(7 citation statements)

References 22 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our survey reveals the different HPLC methods used in the analysis of OLZ. The data are presented in Table 4 (Chiu & Franklin, 1996; D'Arrigo et al, 2006; Dusci et al, 2002; Kasper et al, 1999; Marakatham & Shanmugapandiyan, 2022; Pervaiz et al, 2015; Raggi et al, 2000; Siva Selva Kumar & Ramanathan, 2016; Sonawane et al, 2014; Weigmann et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug

Reka

Sheikh

Almalki

et al. 2023

Biomedical Chromatography

View full text Add to dashboard Cite

Olanzapine (OLZ) is an antipsychotic agent and is a thienobenzodiazepine derivative. It is used either in combination with other drugs like carbamazepine, simvastatin, and clozapine or as a single drug. The present work is mainly focused on various approaches for OLZ analysis in bulk drugs as well as on their pharmaceutical formulations. It is also focused on various bioanalytical methods used for analysis. Our survey showed that many analytical techniques were carried out using UV spectrophotometry, MS, LC–MS/MS techniques, and chromatographic techniques like HPLC and high‐performance thin layer chromatography in both bulk and solid dosage forms. Bioanalytical techniques were also performed using human plasma or serum. The analysis was carried out either for a single drug or for a combination of drugs. This review shows the rate of use of the different methodologies for OLZ analysis. A considerable amount of information was collected and utilized for the strategies.

show abstract

Section: Resultsmentioning

confidence: 99%

“…T A B L E 5 Bioanalytical methods for olanzapine using LC-MS/MS. Selva Kumar & Ramanathan, 2016;Sonawane et al, 2014;Weigmann et al, 2001).…”

Section: Olz Bioanalytical Methods Developmentmentioning

confidence: 99%

A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug

Reka

Sheikh

Almalki

et al. 2023

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…The validation procedures were carried out according to US Food and Drug Administration guidelines (USFDA, 2018) as explained previously (Siva Selva Kumar & Ramanathan, 2016). The method was validated for selectivity, specificity, recovery, linearity, accuracy, precision and stability using US Food and Drug Administration (USFDA) guidelines 17 for assay in human urine.…”

Section: Methodsmentioning

confidence: 99%

Exposure of bisphenol A in breast cancer patients—quantitatively assessed by sensitivity‐enhanced high‐performance liquid chromatography coupled with fluorescence detection: A case–control study

Muthusamy

Palanisamy

Ramalingam

2021

Biomedical Chromatography

View full text Add to dashboard Cite

A simple, reproducible and sensitive liquid chromatography (HPLC) method has been developed and validated for estimation of bisphenol A (BPA) in human urine. A simple liquid–liquid extraction technique was used in BPA sample preparation. The analyte was chromatographed on a Shimadzu Prominence HPLC system using isocratic mobile phase conditions at a flow rate of 0.500 ml/min and a Hypersil Gold C18 column maintained at 40°C. Quantification was performed on a fluorescence detector set at excitation 275 nm, emission 313 nm and bisphenol B was used as internal standard. The total run time was 8 min. The method was found to have acceptable sensitivity, selectivity, accuracy (98.82–103.64%), precision (1.17–5.36) and stability in the validation experiment carried out as per the USFDA guidelines. The method sensitivity was as low as 0.50 ng/ml. The applicability of the validated analytical method was established in human patient urine samples. The mean human urine BPA concentrations were 1.18 ± 2.11 ng/ml in the control group and 5.76 ± 6.00 ng/ml in the patient group (P < 0.001). Therefore, this method could be considered as an alternative for routine bio‐monitoring of BPA which is less expensive and feasible in resource‐poor settings.

show abstract

“…To date, common separation methods have been reported for the determination of Risp and 9-OHRisp in various matrices based on HPLC determinations with UV [7][8][9][10][11][12], electrochemical detection [13], or mass spectrometric detection [12,[14][15][16][17], and capillary electrophoresis determinations with UV [18][19][20]. Among the methods mentioned above, some have drawbacks, such as long analysis time or inadequate sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Field‐amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9‐hydroxyrisperidone in beagle dogs

Fan

et al. 2020

J of Separation Science

View full text Add to dashboard Cite

This article describes a method for the simultaneous quantitation of risperidone and its major metabolite, 9‐hydroxyrisperidone, in beagle dog plasma by field‐amplified sample injection in capillary zone electrophoresis. The separation was carried out at 25°C in a 48 cm × 75 µm fused‐silica capillary with an applied voltage of 20 kV using 60 mM NaH2PO4 buffer (pH 3.6). The detection wavelength was 280 nm. Clean‐up and preconcentration of plasma samples were conducted by 96‐well formatted liquid‐liquid extraction. In this study, this stacking technique provided a sensitivity enhancement of approximately 158 to 188 fold compared with the same sample without stacking. The method was suitably validated with respect to stability, specificity, linearity, lower limit of quantitation, accuracy, precision, and extraction recovery. Calibration curves exhibited good linearity (r2 > 0.995) over a wide concentration range of 2.5 to 200 ng/mL for both risperidone and 9‐hydroxyrisperidone. The intra‐ and interday precisions at the three quality control levels were less than 11.40%. The intra‐ and interday accuracies ranged from 87.90 to 107.17% for risperidone and from 88.43 to 105.92% for 9‐hydroxyrisperidone. All validation data were within the required limits. In conclusion, the method developed was successfully applied to pharmacokinetic studies of risperidone and 9‐hydroxyrisperidone in beagle dogs.

show abstract

Concurrent determination of olanzapine, risperidone and 9‐hydroxyrisperidone in human plasma by ultra performance liquid chromatography with diode array detection method: application to pharmacokinetic study

Cited by 10 publications

References 22 publications

A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug

A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug

Exposure of bisphenol A in breast cancer patients—quantitatively assessed by sensitivity‐enhanced high‐performance liquid chromatography coupled with fluorescence detection: A case–control study

Field‐amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9‐hydroxyrisperidone in beagle dogs

Contact Info

Product

Resources

About