Concurrent Deep Vein Thrombosis and Pulmonary Embolism Associated with Hyperthyroidism: a Case Report

Katić, Josip; Katić, Ana; Katić, Karla; Duplančić, Darko; Lozo, Mislav

doi:10.20471/acc.2021.60.02.20

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Although, some trials have failed to show a higher risk of pulmonary embolism in overt or subclinical hyperthyroidism, particularly in the elderly or hospitalized patients [ 130 , 131 ]. Given this scenario, most experts recommend testing thyroid function in unprovoked pulmonary embolism and considering normalizing its function as part of the prevention of thrombotic events recurrence [ 123 , 124 , 132 ].…”

Section: Hyperthyroidism and Vascular Complicationsmentioning

confidence: 99%

Cardiac manifestations in hyperthyroidism

Navajas¹,

Cruz²,

Ordoñez³

et al. 2022

Rev. Cardiovasc. Med.

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Thyroid hormones have a fundamental impact on cardiac function that is mediated by genomic and nongenomic effects, alterations that condition physiological repercussions that lead to changes in frequency, contractility, rhythm and cardiac output as well as an increase in the incidence and prevalence of different cardiovascular diseases. This document presents an updated review of the implications that hyperthyroidism has in different cardiac conditions, including its importance in the evaluation of perioperative cardiovascular risk.

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Section: Hyperthyroidism and Vascular Complicationsmentioning

confidence: 99%

Cardiac manifestations in hyperthyroidism

Navajas¹,

Cruz²,

Ordoñez³

et al. 2022

Rev. Cardiovasc. Med.

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“…Although HT, which affects almost 2% of the world population and is the most common cause of hypothyroidism in Western societies, mostly affects women aged 30-50 years (ratio of 1:10 to 1:20), in their article published in 2022 Jukić et al emphasized the importance of screening older women for subclinical hypothyroidism 4 . According to the literature, thromboembolism due to thyroid hormone elevation in the early stages of HT and permanent hypothyroidism due to iodine-containing drug use in the late stages may be observed 5,6 . What is more worrying is that the prevalence of papillary thyroid cancer (PTC) associated with HT has increased threefold compared to other thyroid diseases, as reported by Dailey et al 7 .…”

Section: ş Pedük and B Koçermentioning

confidence: 99%

Does the Presence of Chronic Lymphocytic Thyroiditis Affect Diagnostic Value of Fine Needle Aspiration Biopsy in Bethesda Category III Nodules?

Pedük

2023

ACC

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This study aimed to determine the relationship between the presence of Hashimoto's thyroiditis (HT) and malignancy rates with prognostic factors in thyroid nodules diagnosed as Bethesda category III, and to examine the effect of HT on diagnostic value of fine-needle aspiration biopsy (FNAB). Demographic information, preoperative examination, and final pathological evaluation of patients with Bethesda category III (AUS-FLUS) nodules who had been operated on in our department over the last 6 years were analyzed. Statistical analyses were performed using the Student's t-test, Mann-Whitney U test and χ 2 -test and logistic regression analysis using SPSS version 22 software. The malignancy rate on final pathology of 159 patients was 24.5%. Malignancy rates were found to be higher in patients with HT coexistence (30.7% vs. 21.5%, p=0.20). Poor prognostic factors such as multifocality, number of metastatic lymph nodes (p=0.04), and extrathyroidal extension were more common in patients with cancer in the pathology specimen who were in the non-HT group. It cannot be said that HT decreases diagnostic value of FNAB in lesions diagnosed with AUS-FLUS. The lower incidence of poor prognostic factors in the HT group may be attributed to cytotoxic cell dominance in tumor immunity.

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“…Previous studies have focused on the relationship between DVT and thyroid diseases, including thyroid dysfunction and thyroid cancer. Some case reports [7][8][9] have demonstrated that hyperthyroidism is often associated with DVT and indicates a worse prognosis [10]. The relationship between thyroid tumors and venous thrombosis has troubled researchers for many years.…”

Section: Introductionmentioning

confidence: 99%

Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

Zhang,

Li,

Yang

et al. 2024

Eur J Med Res

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Background Some previous observational studies have linked deep venous thrombosis (DVT) to thyroid diseases; however, the findings were contradictory. This study aimed to investigate whether some common thyroid diseases can cause DVT using a two-sample Mendelian randomization (MR) approach. Methods This two-sample MR study used single nucleotide polymorphisms (SNPs) identified by the FinnGen genome-wide association studies (GWAS) to be highly associated with some common thyroid diseases, including autoimmune hyperthyroidism (962 cases and 172,976 controls), subacute thyroiditis (418 cases and 187,684 controls), hypothyroidism (26,342 cases and 59,827 controls), and malignant neoplasm of the thyroid gland (989 cases and 217,803 controls. These SNPs were used as instruments. Outcome datasets for the GWAS on DVT (6,767 cases and 330,392 controls) were selected from the UK Biobank data, which was obtained from the Integrative Epidemiology Unit (IEU) open GWAS project. The inverse variance weighted (IVW), MR-Egger and weighted median methods were used to estimate the causal association between DVT and thyroid diseases. The Cochran’s Q test was used to quantify the heterogeneity of the instrumental variables (IVs). MR Pleiotropy RESidual Sum and Outlier test (MR-PRESSO) was used to detect horizontal pleiotropy. When the causal relationship was significant, bidirectional MR analysis was performed to determine any reverse causal relationships between exposures and outcomes. Results This MR study illustrated that autoimmune hyperthyroidism slightly increased the risk of DVT according to the IVW [odds ratio (OR) = 1.0009; p = 0.024] and weighted median methods [OR = 1.001; p = 0.028]. According to Cochran’s Q test, there was no evidence of heterogeneity in IVs. Additionally, MR-PRESSO did not detect horizontal pleiotropy (p = 0.972). However, no association was observed between other thyroid diseases and DVT using the IVW, weighted median, and MR-Egger regression methods. Conclusions This study revealed that autoimmune hyperthyroidism may cause DVT; however, more evidence and larger sample sizes are required to draw more precise conclusions.

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Concurrent Deep Vein Thrombosis and Pulmonary Embolism Associated with Hyperthyroidism: a Case Report

Cited by 4 publications

References 12 publications

Cardiac manifestations in hyperthyroidism

Cardiac manifestations in hyperthyroidism

Does the Presence of Chronic Lymphocytic Thyroiditis Affect Diagnostic Value of Fine Needle Aspiration Biopsy in Bethesda Category III Nodules?

Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

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