Concurrent Cutaneous and Hepatic Hemangiomata in Infancy: Report of a Case and a Review of the Literature

Abstract

Fifty-eight cases of concurrent cutaneous and hepatic hemangiomatosis in infants have been reported in the world literature. A fifty-ninth case is herewith reported and the literature is reviewed. Untreated cases have a mortality rate of 81%, whereas the mortality of treated cases is 29%. The main cause of death appears to be the consequence of arteriovenous shunting in the liver. Early and aggressive treatment by prednisone, radiotherapy to the liver, partial resection of liver, and ligation of the hepatic artery, each alone or in combinations, have been effective.

Development of a testicular haemangioma after interferon therapy for hepatic haemangiomas: a case report

“…It has been reported that the mortality rate of lifethreatening visceral or hepatic haemangiomatosis could be as high as 54% despite the administration of steroids [1]. Recently, IFN therapy has been performed for such severe haemangiomas with almost universally superior results compared to steroid therapy or surgery [3,10].…”

Benign Cutaneous Vascular Tumors of Infancy

“…Hepatic hemangiomas eventually involute, just as they do in the skin, but potentially serious complications may occur during the proliferative phase. 35,36 Most infants with significant liver involvement manifest a triad of hepatomegaly, congestive heart failure, and anemia, which generally develops between 1 and 16 weeks of age. Congestive heart failure is the most common cause of death from disseminated neonatal hemangiomatosis.…”

The sonographic appearance of hepatic hemangioma in utero.

“…11 • 12 With therapy, the mortality rate can be reduced to 29 per cent. 7 Recognition of this lesion in utero can identify the high-risk neonate and lead to early diagnosis and treatment of these frequently lethal lesions.…”