Concurrent cisplatin and 5-fluorouracil chemotherapy and radiation therapy for advanced-stage squamous carcinoma of the vulva

Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States

“…While some studies have shown that oncologists are considered to be early adopters of new therapies when the evidence is clear [20][21], providers may have been hesitant to use less aggressive surgery without additional supporting evidence. Additionally, there may have been insufficient time between publication of the GOG clinical announcement in 1998 [17] and the current study to reflect changes in treatment practices. The Gynecologic Oncology Group is currently investigating the use of preoperative radiation and chemotherapy for advanced vulvar cancer [22].…”

“…Primary chemoradiation has been shown to shrink vulvar cancers dramatically, thus permitting less extensive surgery [17][18][19] and for women with advanced illness (i.e., close/positive margins or metastatic disease in the lymph nodes), adjuvant chemoradiation is recommended. In our study, however, only about 13% of the patients diagnosed with FIGO Stages III or IV in 1999 received chemoradiation for their advanced stage disease while an additional 8-10% received non-concurrent chemotherapy plus radiation.…”

Combined Bleomycin and Irradiation in Preoperative Treatment of Advanced Squamous Cell Carcinoma of the Vulva

“…However, Whitaker et al (17) obtained less favorable results when they used the same regimen to treat patients with more advancd disease. Promising results were reported by Berek et al (18) with concurrent cisplatinl5-FU-radiotherapy. Out of 12 patients treated for primary disease (8 FIGO 3 and 4 FIGO 4), eight showed a complete response.…”

“…The data from Berek et al (18) are nonetheless interesting and promising, and support the use of concomitant chemotherapy and radiotherpay to treat advanced squamous cell carcinoma of the vulva.…”

Antitumor effects on primary tumor and metastatic lymph nodes by superselective intra-arterial concurrent chemoradiotherapy for oral cancer

“…Although it was formerly believed that CDDP enhanced tumor responses to radiation 21,22 , Tanaka et al 23 have experimentally shown that CDDP did not affect cellular radiosensitivity, but that irradiation significantly enhanced CDDP-sensitivity. Therefore, they concluded that an effective protocol would involve the concurrent administration of CDDP with radiotherapy and further administration following completion of radiotherapy in order to achieve higher CDDP sensitivities.…”