Concurrent choice for social interaction and amphetamine using conditioned place preference in rats: Effects of age and housing condition

Yates, Justin R.; Beckmann, Joshua S.; Meyer, Andrew; Bardo, Michael T.

doi:10.1016/j.drugalcdep.2013.02.024

Cited by 69 publications

(88 citation statements)

References 42 publications

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“…More recently, social reward in adolescent and adult males has been shown to reduce cocaine reward when tested using CPP (Fritz, El Rawas, Klement, et al, 2011; Fritz, El Rawas, Salti, et al, 2011; Thiel, Okun, & Neisewander, 2008), suggesting that social interaction competes with cocaine reward. The current results extend these latter findings by showing that AMPH CPP is also reduced by competing social cues in adolescent females, although the peer-associated compartment was not preferred over the AMPH-associated compartment as shown previously in adolescent males (Yates et al, 2013). …”

Section: Discussionsupporting

confidence: 92%

Sex differences in monoamines following amphetamine and social reward in adolescent rats.

Weiss¹,

Hofford²,

Yates³

et al. 2015

Experimental and Clinical Psychopharmacology

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Interaction with social peers may increase rates of drug self-administration, but a recent study from our laboratory showed that social interaction may serve as a type of alternative reward that competes with drug taking in adolescent male rats. Based on those previous results, the current study examined sex differences in preference for social interaction compared to amphetamine (AMPH) in adolescent rats using the conditioned place preference (CPP) paradigm. Similar to previous results with males, females showed AMPH CPP regardless whether they were individual- or pair-housed. In contrast to males, however, females failed to show social CPP, and they did not prefer a peer-associated compartment over an AMPH-associated compartment in a free-choice test. In separate experiments, dopamine (DA) and serotonin (5-HT) metabolite levels were measured in adolescent males and females that were exposed acutely to peer interaction, no peer interaction, AMPH, or saline. In amygdala, levels of the DA metabolite dihydroxyphenylacetic acid (DOPAC) were altered more in response to peer interaction in males than females; in contrast, there was a greater amygdala DOPAC response to AMPH in females. Furthermore, there were greater changes in the 5-HT metabolite 5-HIAA in females than in males following social interaction. These results indicate that the ability of peer interactions to reduce drug reward is greater in adolescent males than females, perhaps due to a greater ability of social cues to activate limbic reward mechanisms in males or a greater ability of AMPH cues to activate limbic reward mechanisms in females.

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Section: Discussionsupporting

confidence: 92%

Sex differences in monoamines following amphetamine and social reward in adolescent rats.

Weiss¹,

Hofford²,

Yates³

et al. 2015

Experimental and Clinical Psychopharmacology

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“…However, there was no compounding effect of SH and adolescent defeat on cocaine self-administration during PR or the 24-hour binge. Some social behaviors, which peak during rat mid-adolescence, are rewarding (Trezza et al 2010), and SH adolescents exhibit increased preference for social contact and engage in social behavior more than group-housed adolescents (Douglas et al 2004; Varlinskaya et al 1999; Yates et al 2013). Thus, social interaction with the resident might be less aversive for SH intruders in the current study to explain the absence of escalated cocaine taking in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior

Burke

Miczek

2015

Psychopharmacology

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Background The link between adolescent social stress and substance abuse is modeled in social defeat of adolescent male rats, at an age when social experiences are essential for neurobehavioral maturation. Objective We investigated the role of social experience and social defeat stress during adolescence on social behavior and cocaine self administration (CocSelfAd) in early adulthood. Methods We manipulated social experience by housing male rats in pairs (PH) or singly (SH) on postnatal day (P) 21. In addition, rats were subjected to social defeat from P35-44. Social behavior was measured during the first and last social defeat in PH and SH adolescents and PH adults. After assessing the behavioral response to novelty and cocaine (P57-61), intra-jugular catheters were implanted and CocSelfAd was analyzed. Results Residents were less aggressive toward PH adolescent intruders compared to PH adult intruders. Adults were submissive and defensive when attacked, whereas PH adolescents froze. In the course of repeated defeats, adolescent PH rats increased freezing, while SH rats decreased freezing. Longer attack-induced freezing after repeated defeats predicted escalated CocSelfAd in adulthood. PH controls acquired CocSelfAd more slowly than PH defeated and SH rats. Defeated PH rats increased CocSelfAd during progressive ratio schedules of reinforcement and during a 24-hour continuous access binge compared to PH controls and SH defeated rats. Conclusions Social defeat in adolescence of PH rats caused persistent increases in adult CocSelfAd. Adolescent PH rats coped with attacks adaptively by increasing freezing behavior after repeated social defeats, a measure that predicted CocSelfAd in adulthood.

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“…For the dependent measure on the postconditioning test, a preference ratio was used which was calculated by dividing the total time spent in the paired context by the total time spent in both the paired and unpaired contexts on this test. The preference ratio is based on previous work by Yates et al [31] and Bardo et al [32]. It has the advantage of easily determining a lack of preference (0.5) and takes into account the amount of time spent in both paired and unpaired contexts on the preference test.…”

Section: Methodsmentioning

confidence: 99%

The Role of Dopamine D<sub>1</sub> and D<sub>2</sub> Receptors in Adolescent Methylphenidate Conditioned Place Preference: Sex Differences and Brain-Derived Neurotrophic Factor

Cummins

Griffin²,

Duty³

et al. 2014

Dev Neurosci

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This study analyzed the role of dopamine D₁ and D₂ receptors in methylphenidate (MPH) conditioned place preference (CPP) in adolescent male and female rats, in addition to the role of these receptors in the effects of MPH on brain-derived neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens. Using a nonbiased CPP procedure, the animals were conditioned from postnatal day (PD) 33 to 37. On conditioning trials, animals were first administered saline or their respective antagonist (0.1 or 0.2 mg/kg SCH-23390; 0.01 or 0.03 mg/kg eticlopride HCl), followed by MPH (5 mg/kg). Approximately 10 min after MPH administration, the rats were placed into the paired context for a 10-min trial. One day after conditioning on PD38, a preference test was administered with dividers removed. One day following the preference test on PD39, brain tissue was removed, and the nucleus accumbens and striatum were analyzed for BDNF. Results revealed that MPH conditioning resulted in an increased preference that was blocked by either dose of SCH-23390, but generally not affected by either dose of eticlopride. Further, the higher dose of SCH-23390 resulted in a conditioned place aversion in males, presumably due to an increased number of dopamine D₁ receptors in adolescent males. MPH produced a significant increase of striatal and accumbal BDNF alleviated by SCH-23390 or eticlopride. These results show that MPH results in CPP in adolescent male and female rats and these effects appear to be mediated by the dopamine D₁ receptor, but the effects of MPH on BDNF appear to be mediated by both dopamine receptor families.

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Concurrent choice for social interaction and amphetamine using conditioned place preference in rats: Effects of age and housing condition

Cited by 69 publications

References 42 publications

Sex differences in monoamines following amphetamine and social reward in adolescent rats.

Sex differences in monoamines following amphetamine and social reward in adolescent rats.

Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior

The Role of Dopamine D<sub>1</sub> and D<sub>2</sub> Receptors in Adolescent Methylphenidate Conditioned Place Preference: Sex Differences and Brain-Derived Neurotrophic Factor

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