Concurrent chemoradiotherapy with nedaplatin in patients with stage IIA to IVA cervical carcinoma

Abstract

Abstract. The present study aimed to evaluate the efficacy and toxicities of nadaplatin-based concurrent chemoradiotherapy (CCRT) in patients with stage IIA to IVA cervical carcinoma. Patients with an International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA cervical carcinoma were treated with nadaplatin-based CCRT, using high-dose rate intracavitary brachytherapy (HDR-ICBT) or radiotherapy (RT) alone, in patients with FIGO stage IIA to IVA cervical carcinoma. CCRT with nedaplatin (80 mg/m 2 ) was administered on Days 1 and 29. The records of 17 women treated either with nadaplatin-based CCRT using HSR-ICBT (n=8) or RT alone (n= 9), for stage IIA to IVA cervical carcinoma were retrospectively reviewed. The activity and toxicity were compared in the two treatment groups. Progression-free survival (PFS) and overall survival (OS) were the main endpoints. The 5-year overall survival rates in the CCRT and RT groups were 68.6 and 77.8%, respectively. The median OS of the CCRT and RT groups was 38.5 and 27.3 months, respectively. There was no significant difference in either PFS (P= 0.618) or OS (P= 0.231). The most common grade 3-4 or higher toxicities in the CCRT groups were leuko-/neutropenia (37.5%). The frequency of acute grade 3-4 toxicity was higher in the CCRT compared to the RT group. However, no statistically significant difference was observed. Nedaplatin-based CCRT was safely performed. Although the prognosis of patients with FIGO stage IIA to IVA cervical carcinoma was not significantly improved, fewer distant relapses were observed in this treatment. Consequently, nedaplatin-based CCRT may be considered as a potential alternative to cisplatin-based CCRT in this patient population.

Hypomagnesemia because of nedaplatin for cervical cancer: A case report

“…Reported side effects include nausea, vomiting, anorexia, alopecia, and nephrotoxicity. There are reports suggesting that nedaplatin in combination with chemoradiation therapy for cervical cancer does not differ in efficacy from cisplatin and may show reduced nephrotoxicity compared with cisplatin 3,4 . Therefore, nedaplatin is listed as an alternative drug in Japanese guidelines when renal function is impaired 5…”

“…There are reports suggesting that nedaplatin in combination with chemoradiation therapy for cervical cancer does not differ in efficacy from cisplatin and may show reduced nephrotoxicity compared with cisplatin. 3,4 Therefore, nedaplatin is listed as an alternative drug in Japanese guidelines when renal function is impaired. A search of the literature for cases of hypomagnesemia associated with nedaplatin did not reveal any similar case reports in the past.…”