Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence

Morisky, Donald E.; Green, Lawrence W.; Levine, David M.

doi:10.1097/00005650-198601000-00007

Cited by 4,392 publications

(3,966 citation statements)

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“…We also found similar results that suggest that side effects of the medication are the principal cause of non-adherence. 9 Very few studies about the diagnostic performance of the Morisky-Green test have generated conflicting results. Although in this study the association between the result of the test and adherence to medication was marginally significant, another study clearly confirmed this association.…”

Section: Discussionmentioning

confidence: 99%

“…8 The independent variables were the four indirect methods: (a) degree of control of HBP on the second visit; (b) knowledge about BP medication, defined as patient capacity to correctly identify antihypertensive medication among the medications prescribed; (c) self-report on adherence defined by answering 'yes' or 'no' to the question 'You think you took your antihypertensive medication as prescribed by physician in the last month'; and (d) the attitude of the patients in relation to their medication as defined in the Morisky-Green test. 9 The test comprised four questions to be answered with 'yes' or 'no': (1) Have you ever forgotten to take your medicine? (2) At times are you not careful about taking your medicine?…”

Section: Methodsmentioning

confidence: 99%

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Validity of four indirect methods to measure adherence in primary care hypertensives

2007

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High blood pressure (HBP) is one of the most important risk factors for morbidity and mortality in the world. Non-adherence to medication is associated with the lack of control of HBP. The objective of this study was to assess the validity of four indirect methods for measuring adherence to medication to control HBP in primary health care. A random sample of 120 hypertensive patients who were undergoing treatment for at least 2 months in a primary care unit in Florianó polis (Brazil) were included in the study. The independent variables were four indirect methods to measure adherence to medication: knowledge regarding the HBP medication, the blood pressure level, attitude regarding the medication intake (Morisky-Green test) and self-reported adherence. The classification of HBP was based on criteria established by the Brazilian Ministry of Health.The gold standard used for measuring adherence was the pill count. Logistic regression was used to estimate sensitivity (highest value of 88.2% for self-report), specificity (highest value of 70.7% for HBP control), positive predictive value (highest value of 46.4% for HBP control) and negative predictive value (highest value of 79.1% for Morisky-Green test) for each of the indirect methods. No indirect method of measuring adherence had a good positive predictive value for adherence, which was best predicted by patients' age and whether they managed to control HBP. The results also revealed low treatment adherence (31.2%) and low control of HBP (37.6%). Non-adherence was mainly associated with side effects of the treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Validity of four indirect methods to measure adherence in primary care hypertensives

2007

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“…Although participants completed study measures at baseline, at 12 weeks (post intervention), and at four other time points for the larger study, only baseline data were used for the current study. The Beck Depression Inventory-II (Beck and Steer, 1987), the Interpersonal Support Evaluation List (Cohen et al, 1985), the HIV Medication-Taking Self-Efficacy Scale (Cha et al, 2004), and one item from the modified Morisky Self-report Medication-Taking Scale (Morisky et al, 1986) were used to assess the variables in this study.…”

Section: Methodsmentioning

confidence: 99%

Mediating roles of medication–taking self-efficacy and depressive symptoms on self-reported medication adherence in persons with HIV: A questionnaire survey

Cha

Erlen

Kim

et al. 2008

International Journal of Nursing Studies

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SummaryWhat is already known about the topic?• Highly active antiretroviral therapy has dramatically decreased morbidity and mortality and improved the quality of life in persons with HIV • Medication-taking self-efficacy beliefs may predict medication adherence in persons with HIV.• Depressive symptoms and perceived social support consistently influence medicationtaking self-efficacy beliefs What this paper adds.• Depressive symptoms mediated the prediction of medication-taking self-efficacy by perceived social support.• Medication adherence self-efficacy mediated the prediction of self-reported medication adherence by perceived social support and depressive symptoms as self-efficacy theory suggests.Correspondence concerning this article should be addressed to EunSeok Cha, #506 Department of Nursing, School of Medicine, ChungAng University 221 Heukseok dong Dongjakgu, Seoul, 156-756, South Korea. Phone: 82-2-820-5769, euc6@cau.ac.kr. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. • This study provides researchers with increased understanding of the mediating role of medication-taking self-efficacy beliefs between selected psychological variables and selfreported medication adherence in persons with HIV. NIH Public AccessBackground-To date, only a few studies have examined the mediating role of self-efficacy on the relationship between depressive symptoms or perceived social support and medication adherence in persons with HIV.Objectives-The purpose of this study was to examine the impact of perceived social support, depressive symptoms and medication-taking self-efficacy on self-reported medication adherence in persons with HIV. A proposed comprehensive model included three mediation hypotheses in order to examine the mediating roles of medication-taking self-efficacy and depressive symptoms Method-Baseline data from "Adherence to Protease Inhibitors" were used. The 215 persons with HIV aged 19-61 (mean= 40.7, SD= 7.58) were recruited from multiple sites in Pittsburgh, PA (USA) and through self-referral. The participants were assessed using the Beck Depression Inventory, Interpersonal Support Evaluation List, the Medication Taking Self-Efficacy Scale, and the modified Morisky Self-report Medication Taking Scale. Structural equation modeling (EQS version 6.1) was used. The Satorra-Bentler Scaled χ 2 test statistics (S-B χ 2 ), comparative fit index (CFI), and the Standardized Root Mean Squared Residual (SRMR) were used to assess the fit of a comprehensive model including three mediation hypotheses.Results-A comprehensive model with the three hypotheses showed a good mode...

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“…Given our focus upon medication adherence, we selected for data analysis only patients who were at risk for nonadherence, as indicated by the well-validated Morisky Medication Adherence Scale (MMAS). 12 Higher MMAS scores reflect poorer adherence, and we used a stringent cutoff of >1 to identify baseline risk for nonadherence. The protocol was approved by our institutional review board.…”

Section: Patient Eligibility and Recruitmentmentioning

confidence: 99%

Potential Impact of Incorporating a Patient-Selected Support Person into mHealth for Depression

et al. 2015

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Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence

Cited by 4,392 publications

References 22 publications

Validity of four indirect methods to measure adherence in primary care hypertensives

Validity of four indirect methods to measure adherence in primary care hypertensives

Mediating roles of medication–taking self-efficacy and depressive symptoms on self-reported medication adherence in persons with HIV: A questionnaire survey

Potential Impact of Incorporating a Patient-Selected Support Person into mHealth for Depression

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