Concurrent acute myositis and Guillain-Barre syndrome in Cytomegalovirus infection – a rare case report

Sakthivadivel, Varatharajan; Palanisamy, Naveenraj; Kachhwaha, Arjun; Kumar, Deepak; Anne, Puneeth Babu; Elhence, Poonam; Meena, Mahadev

doi:10.1186/s12879-020-05506-5

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…GBS is a heterogeneous disorder characterized by rapidly progressive, symmetrical ascending paralysis with areflexia or hyporeflexia triggered by certain infections, such as C. jejuni, cytomegalovirus, M. pneumoniae, Epstein-Barr virus, and Zika virus [4][5][6][7]. Studies done in the past during the 1976 swine flu outbreak revealed that GBS developed after vaccination, with 8.8 cases per million recipients of influenza vaccine being documented [16].…”

Section: Discussionmentioning

confidence: 99%

“…GBS is usually preceded by an infectious trigger by bacterial or viral agents most commonly associated with infection caused by Campylobacter jejuni (C. jejuni) [4]. In addition, recent infections by the Zika virus, Epstein-Barr virus (EBV), and Cytomegalovirus (CMV) have also been reported as antecedent causes of GBS [5][6][7]. Severe acute respiratory syndrome (SARS-CoV-2) infection, resulting in the coronavirus disease 2019 (COVID-19) pandemic, is associated with Guillain-Barré syndrome (GBS) [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 Vaccination a Cause of Guillain-Barré Syndrome? A Case Series

Nagdev¹,

Chavan²,

Sahu³

et al. 2022

Cureus

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Guillain-Barré syndrome (GBS) is a rare autoimmune neuropathic disorder of peripheral nerves usually following an infection or on rarer occasions following vaccinations, but the exact underlying pathophysiology is still unclear. The most common etiology of GBS is a bacterial infection caused by Campylobacter jejuni. Viral infections like Zika virus, Epstein-Barr virus, and Cytomegalovirus also add to the list of GBS etiology. COVID-19 (SARS-CoV-2) has also been reported to cause GBS. Vaccines like the rabies vaccine, influenza vaccine, and poliovirus vaccine account for a very small fraction of Guillain-Barré syndrome. GBS as an adverse effect of COVID-19 vaccination was not reported by the Vaccine Adverse Event Reporting System (VAERS), but an update was later released in the course of the pandemic from FDA news, reporting several patients developing GBS after receiving the COVID-19 vaccine. In this case series, we discuss five cases that developed the GBS post-COVID-19 AstraZeneca vaccine, along with its pathophysiology, management, and outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccination a Cause of Guillain-Barré Syndrome? A Case Series

Nagdev¹,

Chavan²,

Sahu³

et al. 2022

Cureus

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“…Review of the medical literature identified 5 patient case reports of GBS that were complicated with RML ( Table 2 ) ( 5 – 9 ). Therefore, a total of 7 GBS patients experienced concomitant RML.…”

Section: Discussionmentioning

confidence: 99%

“…Some patients initially experience muscle pain or nerve root pain ( 2 ). During the course of GBS, 16–27% of patients show an elevation of serum creatine kinase (CK) levels ( 3 , 4 ) but only rarely is GBS complicated with rhabdomyolysis (RML) ( 5 – 9 ). The research history of GBS in Beijing Children's Hospital (BCH), which is affiliated with Capital Medical University, can be traced back to the 1990s.…”

Section: Introductionmentioning

confidence: 99%

Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review

Yang

Tong²,

Lv³

2022

Front. Pediatr.

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We initially described two children who developed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we found that when GBS “meets” RML, the most prominent characteristics were the following: male dominance; limb weakness, pain and respiratory failure could be caused by multiple factors; limb weakness and respiratory muscle paralysis were more serious than with GBS alone; and the probability of mechanical ventilation was increased. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely identification and intervention to remedy potentially fatal complications such as electrolyte disorder multisystem complications and kidney injury are crucial. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory.

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“…The simultaneous occurrence of GBS and acute myositis has been rarely reported in the literature in the context of acute viral myositis caused by Mycoplasma pneumoniae, Cytomegalovirus, and dengue virus. 13 , 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

About a rare association: Guillain–Barré Syndrome and polymyositis

Chabchoub

Snoussi

Ammar

et al. 2022

Clinical Case Reports

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Guillain-Barré syndrome (GBS) and polymyositis (PM) are two rare autoimmune diseases, one of which affects the peripheral nervous system and other the muscle. We report the case of a young woman with no previous medical history who was hospitalized with an ascending paralysis associated with acute respiratory failure due to a GBS. The patient was treated with plasmapheresis with unfavorable outcome and permanent proximal muscular disability. The diagnosis of an associated PM was retained based on biological myolysis and the results of electromyography and muscular biopsy. To our knowledge, this association of GBS and PM has been reported only once in the literature. The search for syndromic associations in the presence of an autoimmune helps to avoid diagnostic errors.

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Concurrent acute myositis and Guillain-Barre syndrome in Cytomegalovirus infection – a rare case report

Cited by 7 publications

References 18 publications

COVID-19 Vaccination a Cause of Guillain-Barré Syndrome? A Case Series

COVID-19 Vaccination a Cause of Guillain-Barré Syndrome? A Case Series

Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review

About a rare association: Guillain–Barré Syndrome and polymyositis

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