Concurrence of Lupus Erythematosus and Dermatitis Herpetiformis

Thomas, J. R.; Su, W.P. Daniel

doi:10.1001/archderm.1983.01650330032010

Cited by 41 publications

(2 citation statements)

References 24 publications

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“…The Ig deposits must be on or beneath the lamina densa to exclude BP or|; other primary subepidermal bullous diseases associated with antibodies to hemidesmosomal or lamina lucida antigens. It is important to exclude DH because several of its features resemble bullous SLE, and a number of patients with both disorders have been reported [17][18][19][20][21]. Some of those may have been patients with bullous SLE [4,22].…”

Section: Criteria For the Bullous Sle Phenotype And* Exclusion Of Othmentioning

confidence: 99%

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Gammon¹,

Briggaman²

1993

J Invest Dermatol

108

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Bullous systemic lupus erythematosus (SLE) is a rare blistering disease with a distinctive combination of clinical, histologic and immunopathologic features that together constitute a unique bullous disease phenotype. There appear to be at least two immunologically distinct subtypes of bullous SLE characterized by the presence or absence of circulating and/or tissue-bound basement membrane zone autoantibodies that recognize type VII collagen. The two subtypes are not clearly distinguishable except by indirect immunofluorescence and/or direct immunoelectron microscopy. In patients without circulating antibodies, immunoelectron microscopy is required to distinguish between the two subtypes. Patients with autoantibodies to type VII collagen are similar but not identical to patients with epidermolysis bullosa acquisita--another bullous disease associated with autoantibodies to type VII collagen. Autoantibodies to type VII collagen in patients with bullous SLE is only one of several lines of evidence that indicate autoimmunity to that protein and susceptibility to SLE are associated phenomena. In addition, there is emerging evidence for an association between epidermolysis bullous acquisita and SLE. There is also evidence that autoantibodies to type VII collagen are pathogenic in bullous SLE (and epidermolysis bullosa acquisita) and that their production is regulated by the class II major histocompatibility complex DR beta 1 allele, 1501 and possibly other DR beta 1 alleles that share a similar sequence of amino acids in the second hyper-variable region.

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Section: Criteria For the Bullous Sle Phenotype And* Exclusion Of Othmentioning

confidence: 99%

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Gammon¹,

Briggaman²

1993

J Invest Dermatol

108

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“…glomerulonephritis [3], thyroidi tis, Sjögren syndrome, pernicious anemia, systemic lupus erythematosus [4] and ulcer ative colitis [5,6], and is regarded as a skin manifestation due to a 'generalized distur bance in immunity' [7], Despite the lack of cartilage histology, the diagnosis of RP can be accepted in this case in the presence of three clinical criteria as defined by MacAdam et al [8] and the presence of type II col lagen antibodies detected by the Foidart technique [2]. Like DH, RP frequently oc curs in association with or during the course of other conditions whose pathogenesis in volves immune dysfunction [9].…”

Section: Commentmentioning

confidence: 99%

Dermatitis herpetiformis Associated with Relapsing Polychondritis

Laurent

Humbert²,

Fellman³

1988

Dermatology

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A 35-year-old woman developed typical relapsing polychondritis within a year following the onset of dermatitis herpetiformis. This occurred during a reduction in the dapsone dose regimen. To our knowledge, the coexistence of these two conditions in a single patient has not yet been reported in the literature. Both the parallel course and the good response to dapsone suggest a pathogenic link between these two diseases.

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Coincidence or Substantive Relationship?

Schwartz¹

1984

Arch Dermatol

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Concurrence of Lupus Erythematosus and Dermatitis Herpetiformis

Cited by 41 publications

References 24 publications

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Dermatitis herpetiformis Associated with Relapsing Polychondritis

Coincidence or Substantive Relationship?

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