Concurrence of erythema migrans and herpes simplex: first description of a highly unusual dual skin infection

Painful blister‐free HSV‐type 1 reactivation on the site of acute Lyme borreliosis

“…To our knowledge, concurrence of EM and HSV has only been reported once, but multiple confluent vesicles were present on the erythema. 4 Atypical HSV-reactivation without vesicle formation has been described on mucous membranes, 5 but in our patient it occurred on the skin. Noteworthy, HSV-DNA polymerase is frequently found in post-herpetic erythema multiforme and in erythema multiforme-like lesions after stem cell transplantation.…”

“…1,2 Cidofovir is a potent antiviral agent that has been used (off label) for the topical treatment of viral warts, including isolated cases of RW located on anogenital area , and feet, mostly in immunosuppressed patients. 3,4 We undertook a retrospective observational study of patients with warts who received treatment with cidofovir cream at the Dermatology Department of the Costa del Sol Hospital between January 2010 and June 2014. The aim was to assess the response (complete, partial and none) to this treatment related to the characteristics of the study population and determine predictive factors of good response.…”