Concurrence of Anorexia Nervosa and Noonan Syndrome

Arvaniti, Aikaterini; Samakouri, Maria; Keskeridou, Flora; Veletza, Stavroula

doi:10.1002/erv.2261

Cited by 7 publications

(3 citation statements)

References 26 publications

(31 reference statements)

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“…11 Bruch & Manthorpe 12 also pointed to short stature as a possible causative factor, adding their finding that concurrences with Turner's syndrome were not above the expected frequency. 12 The interest of the present report, like that of the other case recently published, 13 is that these women, with the features of Turner's but a full chromosome count, had normal hormonal function, arguing against a predisposition.…”

Section: Introductionsupporting

confidence: 51%

Concurrence anorexia and pseudo-turner syndrome

Parkinson¹

2018

JPCPY

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Objective: While more than twenty concurrences of anorexia nervosa with turner's syndrome (45X0) have been reported, this is the second report of a concurrence with the Turner Phenotype (46,XX). Method: Patient's history, hospital presentation and progress are described. Results: Dieting would convert a plump, baby-like figure to a normally proportioned though miniature adult. There were mood swings and paranoid episodes. Conclusions: Short stature seems a key factor when anorexia occurs in Turner's patients.

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Section: Introductionsupporting

confidence: 51%

Concurrence anorexia and pseudo-turner syndrome

Parkinson¹

2018

JPCPY

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“…A handful of adult case reports have reported co-occurrence of NS and other psychiatric diagnoses including alcohol abuse, anorexia nervosa, bipolar disorder panic disorder, obsessivecompulsive disorder, and schizophrenia (Arvaniti et al 2014;Noonan 2005;Wingbermühle et al 2009). Nevertheless, given the dearth of these types of published reports, there is no clear evidence to suggest that serious mental illness is more common in NS than in the general population.…”

Section: Psychopathology/mental Healthmentioning

confidence: 99%

Neuropsychological Functioning in Individuals with Noonan Syndrome: a Systematic Literature Review with Educational and Treatment Recommendations

Pierpont

2015

J Pediatr Neuropsychol

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Noonan syndrome (NS) is a relatively common genetic syndrome with variable features including short stature, congenital heart disease, distinctive facial characteristics, skeletal anomalies, and varying degrees of developmental delay. NS is caused by gene mutations in a cellular signaling pathway that is essential for typical growth and development. Research in the past few decades has revealed that individuals with NS have highly variable neurocognitive and behavioral outcomes. To a certain extent, variability in cognitive functioning depends on the particular gene where a mutation is found; additionally, factors related to medical severity and environmental effects contribute substantially to outcomes. This article contains a systematic review of research on neuropsychological features of NS, including cognition, motor development, language, memory, attention, visual perception, adaptive behavior, social skills, and mental health concerns. Given the wide variety of possible cognitive and behavioral complications associated with NS, it is recommended that clinical neuropsychological evaluation of cognitive, adaptive, and psychological domains of functioning should be standard of care for all individuals with NS. Suggested considerations for assessment of individuals with NS are provided. The paper concludes with recommendations for educational and therapeutic interventions, as well as suggestions for future research directions.

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“…Furthermore, there are incidental reports of psychopathology in adult patients with NS (i.e. schizophrenia, bipolar disorder, panic disorder, obsessive compulsive disorder, alcoholism, oppositional disorder and anorexia nervosa) (Arvaniti, Samakouri, Keskeridou, & Veletza, 2014;Krishna, Abrams, Taylor, & Behar, 1977;Mahendran & Aw, 1989;Noonan, 2005;Verhoeven et al, 2004;Verhoeven, Wingbermühle, Egger, Van der Burgt, & Tuinier, 2008).…”

Section: Introductionmentioning

confidence: 99%

Personality and Psychopathology in Adults with Noonan Syndrome

Roelofs

Wingbermühle

Heijden

et al. 2019

J Clin Psychol Med Settings

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This is the first controlled study regarding personality and psychopathology in adults with Noonan syndrome (NS). Anxiety, depression, alexithymia and symptoms of Attention Deficit-Hyperactivity Disorder and Autism Spectrum Disorder, have been previously described in NS. More information regarding personality and psychopathology in NS could improve mental health care for this population. Therefore, scores on the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), a widely used self-report questionnaire of personality and psychopathology, were compared between patients with NS (n = 18) and matched, healthy controls (n = 18). Furthermore, correlations between MMPI-2-RF scores and alexithymia, measured by the Toronto Alexithymia Scale-20, were investigated. Patients with NS showed significantly higher scores, with medium effect sizes, on MMPI-2-RF scales reflecting infrequent responses (F-r), somatic and cognitive complaints (FBS-r and RBS-r), internalizing problems (EID), demoralization (RCd) and introversion (INTR-r), although the overall profile in both groups was within the non-clinical range. Alexithymia correlated with internalizing problems and negative emotionality in the patient group. In conclusion, patients with NS showed higher levels of introversion, which may predispose them to internalizing problems. These problems were indeed more frequent in patients with NS, especially higher levels of demoralization. Patients may benefit from psychological interventions aimed to decrease internalizing problems, introversion and alexithymia.

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Concurrence of Anorexia Nervosa and Noonan Syndrome

Cited by 7 publications

References 26 publications

Concurrence anorexia and pseudo-turner syndrome

Concurrence anorexia and pseudo-turner syndrome

Neuropsychological Functioning in Individuals with Noonan Syndrome: a Systematic Literature Review with Educational and Treatment Recommendations

Personality and Psychopathology in Adults with Noonan Syndrome

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