Over 50 years of work on group actions on 4-manifolds, from the 1960's to the present, from knotted fixed point sets to Seiberg-Witten invariants, is surveyed. Locally linear actions are emphasized, but differentiable and purely topological actions are also discussed. The presentation is organized around some of the fundamental general questions that have driven the subject of compact transformation groups over the years and their interpretations in the case of 4-manifolds. Many open problems are formulated. Updates to previous problems sets are given. A substantial bibliography is included. CONTENTS 1. Introduction 1 2. Circle and Torus Actions 3 3. The 4-sphere 6 4. Euclidean 4-space 9 5. Simply connected 4-manifolds 10 6. Non-simply connected 4-manifolds 17 7. Gauge-theoretic applications to group actions 19 Appendix A. Update of the Kirby Problem List 23 Appendix B. Update of problems from the 1984 Transformation Groups Conference 23 References 24