Concordance of transient elastography and shear wave elastography for measurement of liver stiffness

O'Hara, Sandra; Hodson, Susan; Hernaman, Chandelle; Wambeek, Nick; Olynyk, John K.

doi:10.1002/sono.12122

Cited by 8 publications

(13 citation statements)

References 12 publications

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“…2 The degree of agreement and the mismatch incidence between the SWE fibrosis score compared to the fibroscan fibrosis score blindly on a specific anatomical level on the patient's body at the midaxillary level which showed more fat level rather than the anterior chest wall. Our methodology was almost similar to O'Hara et al [1], Ryu et al [22], and Roccarina et al [23] who also compared the performance of SWE compared to TE with TE results was the reference values. However, their study was on a fewer sample volume compared with our study which included 180 patients.…”

Section: Discussionmentioning

confidence: 87%

“…Chronic liver disease (CLD) is one of the most common chronic diseases worldwide with multiple etiological factors and high morbidity and mortality rates [1]. CLD caused by multiple factors including alcohol, viral hepatitis, drug induced, auto-immune diseases, and obesity with all these factors leads to liver fibrosis/cirrhosis which may end to liver cell failure and death [2].…”

Section: Introductionmentioning

confidence: 99%

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2D shear wave elastography (SWE) performance versus vibration-controlled transient elastography (VCTE/fibroscan) in the assessment of liver stiffness in chronic hepatitis

2020

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Background: The assessment of liver stiffness and the degree of fibrosis are important factors affecting the management strategy. Multiple non-invasive tools are now available to offer an adequate alternative to biopsy. In this study, we tried to compare the performance of 2D shear wave elastography (SWE) to the transient elastography/fibroscan as a non-invasive tool in the prediction of liver stiffness. This is a prospective study of 215 patients confirmed by serology to have positive virus C or B infection. 2D SWE was done followed by vibrationcontrolled transient elastography (VCTE) known as fibroscan at the same session. Biopsy results were collected. Results: The mean age was 51.07 years ± 6.07 SD. Five cases were excluded due to insufficient data. Fibroscan failed in 30 cases out of 210 cases (failure rate of 14.3%) compared with only 12 patients (6.7% failure rate) while using SWE. Only 180 patients completed the study to the result analysis. SWE results showed significant agreement to the fibroscan results with 86.7% agreement with a tendency for overestimation of the degree of fibrosis (11.7%). The efficacy of SWE was the highest during the assessment of patients with F0 (98.9%), F1 (97.8%), and F4 (93.3%) respectively and relatively low in F2 (92.8%) and F3 (90.6%). Conclusion: 2D SWE is a relatively recent non-invasive tool in the assessment of liver fibrosis grading which can be used as an alternative to the fibroscan with almost similar diagnostic performance especially when fibroscan is not capable to obtain adequate results such as in obesity and ascites.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

2D shear wave elastography (SWE) performance versus vibration-controlled transient elastography (VCTE/fibroscan) in the assessment of liver stiffness in chronic hepatitis

2020

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“…All of these differ in source and detector characteristics, but generally involve ultrasound (>20 kHz) frequencies. Fundamental research relating these non-invasive techniques to more traditional mechanical testing of the liver has also been investigated [269][270][271][272][273]. Konofagou et al [274] emphasized the effects of poroelasticity on the transient elastography response by comparing observations to theoretically calculated profiles.…”

Section: Practical Applicationsmentioning

confidence: 99%

Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective

Rezania

Coombe

Tuszyński

2020

JFB

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Tissue engineering, with the goal of repairing or replacing damaged tissue and organs, has continued to make dramatic science-based advances since its origins in the late 1980’s and early 1990’s. Such advances are always multi-disciplinary in nature, from basic biology and chemistry through physics and mathematics to various engineering and computer fields. This review will focus its attention on two topics critical for tissue engineering liver development: (a) fluid flow, zonation, and drug screening, and (b) biomechanics, tissue stiffness, and fibrosis, all within the context of 3D structures. First, a general overview of various bioreactor designs developed to investigate fluid transport and tissue biomechanics is given. This includes a mention of computational fluid dynamic methods used to optimize and validate these designs. Thereafter, the perspective provided by computer simulations of flow, reactive transport, and biomechanics responses at the scale of the liver lobule and liver tissue is outlined, in addition to how bioreactor-measured properties can be utilized in these models. Here, the fundamental issues of tortuosity and upscaling are highlighted, as well as the role of disease and fibrosis in these issues. Some idealized simulations of the effects of fibrosis on lobule drug transport and mechanics responses are provided to further illustrate these concepts. This review concludes with an outline of some practical applications of tissue engineering advances and how efficient computational upscaling techniques, such as dual continuum modeling, might be used to quantify the transition of bioreactor results to the full liver scale.

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“…Decreasing the distance between the transducer and the liver by finding a better acoustic window or repositioning the patient can help resolve this artifact to a certain extent. Stiffness measurements in the area of dropout should be avoided because of the likelihood of inaccurate measurements and the potential for misdiagnosis . The penetration limitation is the predominant reason why liver SWE measurements must be obtained at a depth of less than 6 to 8 cm below the skin on most commercially available equipment.…”

Section: Common 2d Swe Artifactsmentioning

confidence: 99%

“…Stiffness measurements in the area of dropout should be avoided because of the likelihood of inaccurate measurements and the potential for misdiagnosis. [18][19][20][21] The penetration limitation is the predominant reason why liver SWE measurements must be obtained at a depth of less than 6 to 8 cm below the skin on most commercially available equipment.…”

Section: Penetration Limitation or Dropout Artifactmentioning

confidence: 99%

Propagation Imaging in the Demonstration of Common Shear Wave Artifacts

Dubinsky

Shah

Erpelding

et al. 2018

J of Ultrasound Medicine

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In this article, we describe our experience with shear wave propagation imaging (SWPI) as an adjunct to 2‐dimensional (2D) shear wave elastography (SWE) in a cohort of patients being evaluated for diffuse liver disease. Two‐dimensional SWE has been extensively studied in previous publications; however, 2D SWE using propagation images has not been widely described in the literature to date. We observed that when certain artifacts occurred on the color elastograms, highly characteristic changes to shear wave propagation contours were seen, which can help clarify the cause of the artifacts. To our knowledge, the use of SWPI to explain the etiology of artifacts has never been published before. The artifacts described in this article include the capsule reverberation artifact, penetration limitation or dropout artifact, artifact due to blood vessels, shadowing artifact, tissue motion artifact, and near‐field distortion/precompression artifact. Hence, the purpose of this article is to show examples of common artifacts seen on 2D SWE as depicted on corresponding SWPI to demonstrate that both types of image displays are complementary to each other.

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Concordance of transient elastography and shear wave elastography for measurement of liver stiffness

Abstract: Introduction: Transient elastography is commonly utilised in liver clinics as a non-

Cited by 8 publications

References 12 publications

2D shear wave elastography (SWE) performance versus vibration-controlled transient elastography (VCTE/fibroscan) in the assessment of liver stiffness in chronic hepatitis

2D shear wave elastography (SWE) performance versus vibration-controlled transient elastography (VCTE/fibroscan) in the assessment of liver stiffness in chronic hepatitis

Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective

Propagation Imaging in the Demonstration of Common Shear Wave Artifacts

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