Concordance of positive and negative symptoms in coaffected sib-pairs with schizophrenia

Hwu, Hai-Gwo; Wu, Yuan-Ching; Lee, Sandy F.C.; Yeh, Ling‐Ling; Gwo, Shi-Chin; Hsu, Hey‐Chi; Chang, Ching‐Jui; Chen, Wei-Jen

doi:10.1002/(sici)1096-8628(19970221)74:1<1::aid-ajmg1>3.0.co;2-y

Cited by 17 publications

(2 citation statements)

References 30 publications

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“…Another study of systematically ascertained families in Ireland also failed to detect significant correlations between pairs of affected sibling pairs (ASPs), suggesting that familial factors may not have a significant role in the onset of hallucinations (Kendler et al 1997). Similarly, a study of Chinese ASPs (n = 46 pairs) also did not detect significant correlations with the presence of hallucinations (Hwu et al 1997). …”

Section: Introductionmentioning

confidence: 91%

Correlates of hallucinations in schizophrenia: A cross‐cultural evaluation

Thomas¹,

Mathur²,

Gottesman

et al. 2007

Schizophrenia Research

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Section: Introductionmentioning

confidence: 91%

Correlates of hallucinations in schizophrenia: A cross‐cultural evaluation

Thomas¹,

Mathur²,

Gottesman

et al. 2007

Schizophrenia Research

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“…Studies of familial or genetic influences on other symptom dimensions have been less consistent in their results, but there has been evidence of familiality in some studies [74][75][76][77][78][79][80][81][82][83][84][85][86].…”

Section: Further Clinical Phenotypes and Endophenotypesmentioning

confidence: 99%

Genetics of Schizophrenia and other Psychotic Disorders

Pepper¹,

Cardno²

2014

CPSR

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Abstract:Research into the genetic basis of schizophrenia is advancing rapidly. This review gives a broad overview of results from successive phases of studies in this field, linking these with recent findings and likely future research directions. Among recent findings, large-scale epidemiological studies based on Scandinavian population registers, have provided further evidence of substantial heritability and evidence that a wide range of psychotic and non-psychotic disorders partly share genetic risk factors with schizophrenia. In molecular genetics, large collaborative genomewide association studies (GWAS) are providing evidence of common risk variants, each of small effect, and many more variants are likely to be found as samples sizes increase further. A range of rarer chromosomal copy number variants (CNVs) have been associated with schizophrenia, and both GWAS and CNV studies have provided molecular evidence of genetic overlap between schizophrenia and other disorders. There is increasing interest in phenotypes beyond diagnosis, including further clinical variables and endophenotypes. Next-generation sequencing studies are beginning, with the potential for fast, inexpensive sequencing of the whole genome in large samples, and there is an increasing focus on the functional effects of the candidate risk variants that are being identified.

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Twin study refining psychotic symptom dimensions as phenotypes for genetic research

Cardno

Rijsdijk

Murray

et al. 2008

American J of Med Genetics Pt B

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We investigated which psychotic symptom dimensions are likely to be most useful as phenotypes for genetic linkage and association studies. Two hundred twenty-four probandwise twin pairs (106 monozygotic,118 same-sex dizygotic), where probands had psychosis, were ascertained from the Maudsley Twin Register in London. Dimensions were defined as ordinal symptom scores using the OPCRIT checklist, based on previous factor analyses of this and other samples. To qualify as a potentially useful phenotype, dimensions had to show (a) a satisfactory polychoric model fit and significant within-pair correlation in MZ pairs concordant for DSM-III-R psychosis and (b) that they could not be better defined in terms of other combinations of relevant symptoms, single symptoms, or dichotomized dimension scores. Relationships between dimension scores in twin probands and risk of psychosis in co-twins were also investigated. None of the positive or negative dimensions satisfied the phenotypic criteria. The disorganized dimensions showed significant and substantial correlations which maximized for a narrow definition. Combined negative/disorganized dimensions also showed significant and substantial correlations, but did not have advantages over disorganized dimensions. None of the dimensions were significant predictors of psychosis risk in co-twins. We conclude that, of the dimensions analyzed, the narrow disorganized dimension shows most promise as a phenotype for molecular genetic research.

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Concordance of positive and negative symptoms in coaffected sib-pairs with schizophrenia

Cited by 17 publications

References 30 publications

Correlates of hallucinations in schizophrenia: A cross‐cultural evaluation

Correlates of hallucinations in schizophrenia: A cross‐cultural evaluation

Genetics of Schizophrenia and other Psychotic Disorders

Twin study refining psychotic symptom dimensions as phenotypes for genetic research

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