Concordance of atopic and affective disorders

Nasr, Suhayl; Altman, Edward G.; Meltzer, Herbert Y.

doi:10.1016/0165-0327(81)90030-6

Cited by 73 publications

(31 citation statements)

References 18 publications

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“…As previously reported [5], subjects with a history of clinical levels of depression (i.e. DEPDX group) reported a much higher prevalence of allergies, especially asthma and hay fever, than did those without the affective disorder diagnosis.…”

Section: Discussionsupporting

confidence: 52%

Depression and Allergies: Survey of a Nonclinical Population

Bell

Jasnoski

Kagan

et al. 1991

Psychother Psychosom

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The possible association between depression and type I allergies (i.e. immunoglobulin E-mediated hay fever, asthma, eczema, hives) was examined in a nonclinical sample of 379 college students. Measures included self-reports of depression, tiredness, fearfulness, allergic disorders, and environmental allergens and irritants. Seventy-one percent of the subjects who had ever received a professional diagnosis of depression also indicated a history of allergy; those with greater self-rated current depression overall reported a significantly higher prevalence of asthma (p < 0.05). Type I allergic (43%) and nonallergic subjects did not differ in self-rated frequency of depression, fatigue, or anxiety. However, type I subjects reported significantly worse mood after the flu than did nonallergic subjects (p < 0.001). The data support the hypothesis that individuals prone to clinical depression have more allergies than nondepressives. Allergies may experience more postflu mood worsening but not current depression in comparison with nonallergics.

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Section: Discussionsupporting

confidence: 52%

Depression and Allergies: Survey of a Nonclinical Population

Bell

Jasnoski

Kagan

et al. 1991

Psychother Psychosom

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“…Several studies have suggested that there is an association between allergies, or atopic diseases, and affective disorders [Ossofsky, 1976;Nasr et al, 1981;Sugerman et al, 1982;Bell et al, 1991;Wamboldt et al, 1996]. Recently, Wamboldt et al [2000] reported in this journal an association between self-reported indices of atopic illness and at least moderate depression, according to the Beck Depression Index (BDI), in a large sample of Finnish adult twins.…”

Section: To the Editorsmentioning

confidence: 92%

Association between atopic disorders and depression: Findings from the Northern Finland 1966 birth cohort study

et al. 2001

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“…Higher than normal rates of IgE-mediated allergies have been reported in adults with depression [Bell et al, 1991;Kennedy et al,1996;Nasr et al, 1981;Ossofsky, 1976;Sugerman et al, 1982], panic disorder [Jasnoski et al, 1994;Ramesh et al, 1991;Schmidt-Traub and Bamler, 1997], social anxiety [Bell et al, 1990[Bell et al, , 1993, and in children with inhibited temperament Rosenberg and Kagan, 1989] and attention deficity/hyperactivity disorder [Roth et al, 1991;Marshall, 1989]. Although an association between allergic disorders and emotional symptoms has been reported in the clinical literature, the nature of the relationship remains unclear.…”

Section: Introductionmentioning

confidence: 94%

Familial association between allergic disorders and depression in adult Finnish twins

et al. 2000

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Clinical studies have shown a relationship between allergic disorders and depression, panic disorder, attention deficit/hyperactivity disorder, and social anxiety for a significant subset of patients with these disorders. The nature of the relationship, whether due to shared environmental or biologic vulnerabilities or as a result of the stress of chronic illness, has been less clear. By examining the covariance of atopic disorders and depressive symptoms in a community sample of monozygotic (MZ) and dizygotic (DZ) twins, the contribution of genetic and/or shared environmental etiological factors can be established. A Finnish sample of 1337 MZ and 2506 DZ twin pairs, ages 33-60 years, was sent questionnaires inquiring about history of asthma, eczema, and atopic rhinitis, as well as the Beck Depression Inventory (BDI). The nature of the covariation between twins of these symptoms was investigated by fitting competing genetic and environmental models. Within-person correlation between atopic symptoms and BDI was 0.103 (P < 0.001) for the total sample. Using the Mx statistical modeling program to fit the data to competing quantitative genetic models, the best fitting model estimated that 64% of the association between atopy and BDI was due to shared familial vulnerability, primarily additive genetic influences. Although the measures for allergic disorders and depression are crude, this study supports the hypothesis that there is a small shared genetic risk for atopic and depressive symptoms, and if replicated, may open research for common mechanisms between allergic and depressive disorders. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:146-153, 2000.

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Concordance of atopic and affective disorders

Cited by 73 publications

References 18 publications

Depression and Allergies: Survey of a Nonclinical Population

Depression and Allergies: Survey of a Nonclinical Population

Association between atopic disorders and depression: Findings from the Northern Finland 1966 birth cohort study

Familial association between allergic disorders and depression in adult Finnish twins

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