Concordance of allelic imbalance profiles in synchronous and metachronous bilateral breast carcinomas

Imyanitov, Evgeny N.; Suspitsin, Evgeny N.; Grigoriev, M.; Togo, Alexandr V.; Kuligina, Ekatherina Sh.; Belogubova, Evgeniya V.; Pozharisski, Kazymir M.; Turkevich, E A; Rodriquez, Carmen; Cornelisse, Cees J.; Hanson, Kaido P.; Theillet, Charles

doi:10.1002/ijc.10530

Cited by 64 publications

(70 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…See Table 1 for case numbers and a detailed description of the genomic imbalances. supporting the conclusion that most patients with bilateral breast carcinomas have two different diseases (Dawson et al, 1991;Sterns and Fletcher, 1991;Pandis et al, 1995;Shibata et al, 1996;Imyanitov et al, 2002). This notwithstanding, one of the patients presented two bilateral lobular carcinomas sharing all five genomic imbalances by CGH, strongly arguing that one tumour must have metastasised to the contralateral breast, as we have also seen occasionally before (Pandis et al, 1995).…”

Section: Discussionsupporting

confidence: 79%

“…Among the principles used have been X-inactivation analysis (Noguchi et al, 1994a, b;Shibata et al, 1996), comparisons of allelic imbalance patterns (Tsuda and Hirohashi, 1995;Imyanitov et al, 2002), or the distribution of TP53 point mutations (Ackerman et al, 1995;Kinoshita et al, 1995;Shibata et al, 1996), but these studies depend heavily on statistical group comparisons and therefore are of limited value in individual patients. We have in the past successfully assessed the pathogenetic and clonal relationships among multiple breast tumours by means of chromosome banding analysis with karyotyping (Pandis et al, 1995;Teixeira et al, 1994Teixeira et al, , 1997.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis

et al. 2004

View full text Add to dashboard Cite

The issue of whether multiple, ipsilateral or bilateral, breast carcinomas represent multiple primary tumours or dissemination of a single carcinomatous process has been difficult to resolve, especially for individual patients. We have addressed the problem by comparative genomic hybridisation analysis of 26 tumours from 12 breast cancer patients with multiple ipsilateral and/or bilateral carcinoma lesions. Genomic imbalances were detected in 25 of the 26 (96%) tumours. Using the genomic imbalances detected in these 26 lesions as well as those previously found by us in an independent series of 35 unifocal breast carcinomas, we compared a probabilistic model for likelihood of independence with unsupervised hierarchical clustering methodologies to determine the clonal relatedness of multiple tumours in breast cancer patients. We conclude that CGH analysis of multiple breast carcinomas followed by unsupervised hierarchical clustering of the genomic imbalances is more reliable than previous criteria to determine the tumours' clonal relationship in individual patients, that most ipsilateral breast carcinomas arise through intramammary spreading of a single breast cancer, and that most patients with bilateral breast carcinomas have two different diseases.

show abstract

Section: Discussionsupporting

confidence: 79%

mentioning

confidence: 99%

Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Janschek et al investigated TP53 mutations across 33 patients, but were due to the singlegene assay and lack of normal tissue, only able to determine the clonal status for 13 patients, of which two were determined to have a metastasis rather than a second primary. Imyanitov et al determined status for all but one of 28 investigated cases, using 14 fixed markers for each tumor [5], showing a higher similarity between synchronous CBC than metachronous CBC. Two studies have used CGH to investigate the relationship between the tumors, showing that investigation of genomic imbalances can be used to detect recurrent breast tumors in both the ipsilateral and contralateral settings [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Women with breast cancer have, 20 years after their initial diagnosis, 10-15% cumulative incidence of second primary breast cancer in the opposite breast; contralateral breast cancer (CBC) [4,5]. We and others have previously shown that women with CBC have significantly worse prognosis compared to women with unilateral cancer [2,3].…”

Section: Introductionmentioning

confidence: 99%

Exome sequencing of contralateral breast cancer identifies metastatic disease

Klevebring

Lindberg

Rockberg

et al. 2015

Breast Cancer Res Treat

View full text Add to dashboard Cite

“…First, in accordance with other studies, bilateral breast carcinomas are genetically unrelated. [2][3][4] Second, like in unilateral invasive and noninvasive breast carcinomas, LR of breast carcinoma is most likely related to the preceding carcinoma of the ipsilateral breast and not a de novo occurring carcinoma. 22,24 Third, like in unilateral breast carcinomas, LR in bilateral carcinomas is also characterized by an increase of genetic alterations.…”

Section: Discussionmentioning

confidence: 99%

Bilateral carcinomas of the breast with local recurrence: analysis of genetic relationship of the tumors

Regitnig¹,

Ploner

Maderbacher³

et al. 2004

Modern Pathology

View full text Add to dashboard Cite

Local recurrence of bilateral breast carcinomas is rare, but of biological interest, since it is unclear as to which tumor the local recurrence is related to, the ipsilateral or the contralateral, or whether it is an independent neoplasm. The aim of this study was to investigate the genetic relationship of bilateral breast carcinomas to each other and to their local recurrences. Eight cases of bilateral breast carcinomas, five with and three without local recurrence were analyzed using a microsatellite assay for 13 microsatellite loci. The presence of loss of heterozygosity and microsatellite instability in the various tumors was used for clonal analysis. All eight bilateral breast carcinomas showed divergent alterations in at least two microsatellite loci, which ruled out a genetic relationship. Four of five local recurrences were genetically related to the ipsilateral tumor and unrelated to the contralateral tumor. Only one local recurrence that occurred 11.8 years after the surgery of an infiltrative lobular carcinoma simultaneously with distant metastases was genetically related to the contralateral breast carcinoma. Although the number of cases in our study is limited, there is evidence that local recurrence of bilateral breast carcinoma frequently arises from the ipsilateral tumor. Keywords: bilateral breast carcinoma; local recurrence; microsatellite analysis; loss of heterozygosity; clonality Epidemiologic data on breast carcinomas show that 2-11% of breast carcinoma patients will develop contralateral breast carcinoma in their lifetime. Women with unilateral breast carcinoma are at a 2-6-fold increased risk of developing contralateral breast carcinoma, compared to the risk in the general population. 1 Bilateral breast carcinomas are of particular interest with respect to their relationship, whether they represent independent neoplasms or occur by metastatic tumor spread. This issue becomes more complex in the setting of local tumor recurrence. In this situation, the question arises whether the local recurrence is related to one of the bilateral tumors or is an independent, de novo arising neoplasm, or whether both of the tumors and the recurrence are metastases of the other tumor. The fact that whether bilateral breast carcinomas and its local recurrence have to be considered a local or a metastatic process has important therapeutic and prognostic implications.A second independently arising breast carcinoma is favored, if the histological tumor types are different. However, if the histological tumor types are identical, the distinction between a subsequently occurred novel tumor and a local recurrence of the original tumor is difficult. Conventional parameters such as the histopathological grade and various immunohistochemical analyses such as estrogen, progesterone and HER-2/neu receptor expression are not reliable to prove the relationship of these tumors.During recent years, several studies using different molecular methods have indicated that bilateral breast carcinomas are most likely genetically u...

show abstract

Concordance of allelic imbalance profiles in synchronous and metachronous bilateral breast carcinomas

Abstract: Bilateral breast cancer (biBC) is a common form of breast cancer; however, it has not been subjected to systematic comparative genetic studies. We allelotyped 28 biBCs on 14 chromosomal arms, addressing 2 lines of questions: (

Cited by 64 publications

References 16 publications

Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis

Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis

Exome sequencing of contralateral breast cancer identifies metastatic disease

Bilateral carcinomas of the breast with local recurrence: analysis of genetic relationship of the tumors

Contact Info

Product

Resources

About