Concordance Between Patient and Clinician Assessment of Dry Eye Severity and Treatment Response in Taiwan

Yeh, Po-Ting; Chien, Hsu-Chih; Ng, Kwong; Tseng, Sung-Huei; Chen, Wei-Li; Hou, Yu-Chih; Wang, I‐Jong; Chu, Hsiao-Sung; Yang, Yea‐Huei Kao; Hu, Fung‐Rong

doi:10.1097/ico.0000000000000409

Cited by 11 publications

(13 citation statements)

References 35 publications

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“…Thus, there may be some disconnect between clinical assessment of “effectiveness” and patients’ perception of “relief” associated with current medications use. Patient- and physician-reported assessments of DED severity often diverge and, despite reports of patient experience being positively associated with clinical effectiveness, contrary reports of patient experience often being not in concordance with clinical assessments also exist [28, 29]. The fact that symptoms, causes and especially treatments of DED are most frequently discussed in the context of their impact on patients’ lives in the current study, points to the practical concerns that are most bothersome to patients; these may differ from clinical measures of improvement.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Patient Experiences in Dry Eye Disease Through Social Media Listening Research

et al. 2019

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Introduction Social media listening (SML) is an approach to assess patient experience in different indications. This is the first study to report the results of using SML to understand patients’ experiences of living with dry eye disease (DED). Methods Publicly available, English-language social media content between December 2016 and August 2017 was searched employing pre-defined criteria using Social Studio ® , an online aggregator-tool for posts from social media channels. Using natural language processing (NLP), posts were indexed using patient lexicon and disease-related keywords to derive a set of patient posts. NLP was used to identify relevance, followed by further manual evaluation and analysis to generate patient insights. Results In all, 2279 possible patient records were identified following NLP, which were filtered for relevance to disease area by analysts, resulting in a total of 1192 posts which formed the basis of this study. Of these, 77% ( n = 915) were from the USA. Symptoms, causes, diagnosis and treatments were the most commonly discussed themes. Most common symptoms mentioned were eye dryness (138/901), pain (114/901) and blurry vision (110/901). Pharmaceutical drugs (prescription and over-the-counter; 55%; 764/1393), followed by medical devices (20%; 280/1393), were mentioned as major options for managing symptoms. Of the pharmaceutical drugs, eye drops (33%; 158/476) and artificial tears (10%; 49/476) were the most common over-the-counter options reported, and Restasis ® (22%; 103/476) and Xiidra ® (6%; 27/476) were the most common prescription drugs. Patients voiced a significant impact of DED on their daily activities (4%; 9/224), work (23%; 51/224) and driving (12%; 26/224). Lack of DED specialists, standard diagnostic procedures, effective treatment options and need to increase awareness of DED among patients were identified as the key unmet needs. Conclusions Insights revealed using SML strengthen our understanding about patient experiences and their unmet needs in DED. This study illustrates that an SML approach contributed effectively in generating patient insights, which can be utilised to inform early drug development process, market access strategies and stakeholder discussions. Funding Novartis Pharma AG, Basel, Switzerland. Plain Language Summary Plain language summary available for this article. Electronic supplementary material The online version of this article (10.1007/s40123-019-0188-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Evaluating Patient Experiences in Dry Eye Disease Through Social Media Listening Research

et al. 2019

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“…Furthermore, the severity between symptoms and signs of dry eye may be inconsistent in this study. Yeh et al 44 demonstrated a low agreement between clinicians and patient assessments in dry eye severity, which may explain the inconsistency. Because the results of the differences between groups and before and after treatment are inconsistent in some parameters, it is hard to make a strong conclusion.…”

Section: Discussionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

Huang

Yeh

Hou

2016

OPTH

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PurposeTo evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES).MethodsA prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus) with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer’s test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS) in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance.ResultsForty-three patients, 20 and 23 in treatment and placebo groups, respectively, completed the study. Liver and renal functions were normal. Diastolic blood pressure decreased in the treatment group. There were no significant differences in systolic blood pressure, dry eye symptoms, serum anti-SSA and anti-SSB, visual acuity, intraocular pressure, or fluorescein corneal staining between the groups. Tear film breakup time scores and Schirmer’s test without topical anesthesia significantly improved in the treatment group. Tear ROS level differed between the groups and decreased after treatment. Overall subjective impression revealed a significant improvement with treatment compared with placebo.ConclusionOral antioxidant supplementations may increase tear production and improve tear film stability by reducing tear ROS. The vegetable-based antioxidant supplement used in this study is safe and can be utilized as an adjuvant therapy to conventional artificial tear therapy for patients with DES.

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“…Based on OSDI score, the ocular surface is defined as normal (0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), or severe (33-100) [44]. It is noteworthy that although the OSDI is not routinely used in clinical practice, it has been shown to be valid and reliable to quantify the impact of dry eye on the quality of life [44].…”

Section: Discussionmentioning

confidence: 99%

Methods for detection of dry eye in critically ill patients: An Integrative Review

Câmara¹,

Araújo²,

Fernandes³

et al. 2016

Int Arch Med

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Concordance Between Patient and Clinician Assessment of Dry Eye Severity and Treatment Response in Taiwan

Cited by 11 publications

References 35 publications

Evaluating Patient Experiences in Dry Eye Disease Through Social Media Listening Research

Evaluating Patient Experiences in Dry Eye Disease Through Social Media Listening Research

A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

Methods for detection of dry eye in critically ill patients: An Integrative Review

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