Concordance and comorbidities among monozygotic twins with tic disorders

Pedersen, Julie Holst; Skytthe, Axel; Bybjerg‐Grauholm, Jonas; Kücükyildiz, Asli Sena; Skov, Lone; Debes, Nanette Mol; Tümer, Zeynep

doi:10.1016/j.jpsychires.2021.11.019

Cited by 4 publications

(1 citation statement)

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“…Those with a family history of suicide exhibited a higher incidence of suicide and attempted suicide compared to those without the family history (6). The co-morbidity rate is found to be higher in monozygotic twins compared to dizygotic twins (7). The twin study revealed that the concurrent rate of suicide attempts among monozygotic twins (23.1%) was significantly higher, approximately 17 times higher, compared to the rate of suicide attempts observed in the entire sample (8).…”

Section: Genetic Contribution Of Serotonin To Suicidementioning

confidence: 84%

A Comparison of Genetic versus Non-Genetic Contribution of Serotonin to Suicide

Lee

2023

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Suicide is a complex and multifaceted public health issue that has been intensively studied to identify its contributing factors. Serotonin, a neurotransmitter essential for affective regulation and mood control, has been linked to suicidal propensity. Understanding the relative contribution of serotonin’s genetic versus non-genetic influences is essential for the development of effective preventive measures, given that the etiology of suicide involves both genetic and non-genetic factors. This review seeks to compare the influence of genetic and non-genetic factors on the association between serotonin and suicide risk. Examining serotonin-related gene polymorphisms, with a focus on the serotonin transporter gene, the serotonin receptor 1A, and the serotonin receptor 2A, genetic contributions are investigated. This review emphasizes the complex interplay between genetic and non-genetic contributions to serotonin’s role in suicide by synthesizing existing literature. Understanding these complex interactions can provide a comprehensive framework for targeted interventions and individualized methods of suicide prevention and mental health promotion. Future research should incorporate large-scale genetic studies, genetic and non-genetic interaction analyses, and longitudinal designs in order to further elucidate the complex relationship between serotonin and suicide risk.

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Section: Genetic Contribution Of Serotonin To Suicidementioning

confidence: 84%