Concomitant uveal melanoma and papillary thyroid carcinoma: a case report

Abstract

Background Melanoma develops in the cells that produce melanin; ocular melanoma accounts for 3–4% of all malignant melanomas. Thyroid tumors are the most common endocrine neoplasms, with more than 95% of cases arising from follicular cell origin. Previous studies have reported associations between malignant melanoma and a wide variety of malignancies. Case presentation We report a 54-year-old Iranian woman who was diagnosed with ocular melanoma based on a mushroom-shaped filling defect with homogeneous echo pattern arising from the anterior third of the temporal side of the globe detected on ocular sonography during routine ophthalmological examination. She underwent right globe enucleation and implant replacement. During tumor surveillance, fluorodeoxyglucose positron emission tomography/computed tomography scan showed low-grade metabolically active tumoral involvement in the anterolateral aspect of the right lobe of thyroid. The patient subsequently underwent thyroidectomy and submandibular lymphadenectomy. Pathologic report demonstrated micropapillary carcinoma (9 × 8 mm2), tall cell variant without lymphovascular or perineural invasion in the base of lymphocytic thyroiditis. Conclusion This case illustrates the importance of precise active surveillance in case of papillary carcinoma of thyroid or malignant melanoma to avoid missing other associated pathologies and emphasizes the simultaneous treatment of two tumors.

Management of primary anorectal mucosal melanoma during the COVID-19 pandemic

“…The medical history of our patient also led us to consider whether previous cancer or cancer treatment may increase the risk of MAM. Three case reports showed relevant results: diagnosis of MAM after breast cancer treatment [ 3 ], metachronous thyroid cancer and MAM [ 21 ] and concomitant uveal melanoma and thyroid cancer [ 22 ]. In addition, a history of thyroid cancer appears to increase the risk of cutaneous melanoma and vice versa [ 23 , 24 ].…”

Is Melanoma Progression Affected by Thyroid Diseases?

“…Several studies documented a clear association between thyroid cancers and melanoma [ 1 , 7 , 15 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. Patients with melanoma have a 2.3-fold higher risk of developing a PTC, while patients with PTC have a 1.8-fold higher risk of getting melanoma [ 84 ].…”