Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report

Mitsogianni, Maria; Mitsimponas, Nikolaos; Crespo, F. Chavarría; Hartmann, Karl; Klosterhalfen, B.; Haase, Sabine; Giagounidis, Aristoteles

doi:10.1159/000486640

Cited by 5 publications

(2 citation statements)

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“…The BRAF gene is mutated in 1–5% of NSCLC cases and most of these mutations occur in adenocarcinoma (14). BRAF is a member of the RAF family of serine/threonine kinases that mediate signal transduction between RAS and mitogen-activated protein kinase (MAPK) signaling pathways (15). Once the mutation is activated, the downstream mitogen-actiavted protein kinase (MEK)-extracellular regulated protein kinase signaling pathway is activated continuously, resulting in the excessive proliferation and survival of tumor cells (Fig.…”

Section: Discussionmentioning

confidence: 99%

Multiple primary malignant neoplasms: A case report and literature review

et al. 2019

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Until recently, few cases of three or more malignant tumors in one patient have been reported. Owing to the high incidence rate of these tumors, the improvement in cancer diagnosis and treatment, and the extension of patient survival time, the incidence of reported multiple primary malignant neoplasms has gradually increased. The present study reported the case of a 57-year-old man with non-small cell lung cancer combined with B-Raf proto-oncogene serine/threonine kinase V600E mutation, gastrointestinal stromal tumors and lumbar vertebral malignant mucinous sarcoma. The pathogenesis, diagnosis and treatment of these three malignancies are discussed and previous studies are also reviewed. The aim of the study was to analyze the genetic mutations associated with multiple primary malignant tumors and to discuss whether those mutations with unknown functional significance could be used as therapeutic indicators. This case report will serve as a reference for future treatment of such patients.

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Section: Discussionmentioning

confidence: 99%

Multiple primary malignant neoplasms: A case report and literature review

et al. 2019

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“…The reported cancers include hairy cell leukemia, melanoma, and adenocarcinoma of the lung. [22][23][24][25] In conclusion, we report a novel poly-neoplastic syndrome associated with BRAF p.V600E mutation. As next generation sequencing is becoming more available in cancer diagnosis, more cases with this syndrome may be discovered.…”

Section: Discussionmentioning

confidence: 62%

BRAF p.V600E associated poly-neoplastic syndrome

et al. 2021

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We report a male patient who developed eight different cancers between ages 57 and 64. BRAF p.V600E mutation was detected in Langerhans cell histiocytosis, chronic lymphocytic leukemia, histiocytic sarcoma, melanoma, and adenocarcinoma of the lung. It was not detected in multiple myeloma, basal cell carcinoma, and papillary thyroid cancer. BRAF p.V600E was not detected in normal skin tissue biopsy indicating that BRAF V600E was a somatic mutation affecting cancer cells. The presence of eight different cancers with five of them positive for BRAF p.V600E in a single patient is unprecedented. This type of BRAF p.V600E-associated poly-neoplastic syndrome has never been reported in the medical literature.

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