Concomitant leptospirosis-hantavirus co-infection in acute patients hospitalized in Sri Lanka: implications for a potentially worldwide underestimated problem

Sunil-Chandra, N.P.; Clément, Jan; Maes, Piet; Silva, H. J. De; Esbroeck, Marjan Van; Ranst, Marc Van

doi:10.1017/s0950268814003707

Cited by 34 publications

(27 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The clinical underestimation of hantavirus and Leptospira coinfections was recently emphasized. 43 The genus Bartonella contains over 30 named species. Approximately 20 are adapted to wild rodents and six of these have caused documented human infections.…”

Section: Discussionmentioning

confidence: 99%

“…18 Species identification of Apodemus flavicollis and Apodemus sylvaticus was confirmed by PCR (polymerase chain reaction) targeting the mitochondrial cytochrome b gene and sequencing of PCR products. 19,20 A total of 242 animals were collected, including 131 yellow-necked mouse (A. flavicollis), 53 striped field mouse (Apodemus agrarius), three wood mouse (A. sylvaticus), 43 bank voles (Myodes glareolus), six common shrews (Sorex araneus), four common voles (Microtus arvalis), one field vole (Microtus agrestis), and one common dormouse (Muscardinus avellanarius). Animal experimentation guidelines of the American Society of Mammologists was followed during all animal work.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Croatia is a focus for many rodent-borne zoonosis. Here, we report a survey of 242 rodents and small mammals, including 43 Myodes glareolus, 131 Apodemus flavicollis, 53 Apodemus agrarius, three Apodemus sylvaticus, six Sorex araneus, four Microtus arvalis, one Microtus agrestis, and one Muscardinus avellanarius, collected at eight sites in Croatia over an 8-year period. Multiplex MassTag polymerase chain reaction (PCR) was used for detection of Borrelia, Rickettsia, Bartonella, Babesia, Ehrlichia, Anaplasma, Francisella tularensis, and Coxiella burnetii. Individual PCR assays were used for detection of Leptospira, lymphocytic choriomeningitis virus, orthopoxviruses, flaviviruses, hantaviruses, and Toxoplasma gondii. Of the rodents, 52 (21.5%) were infected with Leptospira, 9 (3.7%) with Borrelia miyamotoi, 5 (2%) with Borrelia afzelii, 29 (12.0%) with Bartonella, 8 (3.3%) with Babesia microti, 2 (0.8%) with Ehrlichia, 4 (1.7%) with Anaplasma, 2 (0.8%) with F. tularensis, 43 (17.8%) with hantaviruses, and 1 (0.4%) with an orthopoxvirus. Other agents were not detected. Multiple infections were found in 32 rodents (13.2%): dual infections in 26 rodents (10.7%), triple infections in four rodents (2.9%), and quadruple infections in two rodents (0.8%). Our findings indicate that rodents in Croatia harbor a wide range of bacteria and viruses that are pathogenic to humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…In southern Asia, specifically in India and Sri Lanka, HFRS cases have been reported (Vitarana et al, 1988;Chandy et al, 2009), including those of co-infection with leptospirosis and hantavirus (Sunil-Chandra et al, 2015). However, many patients with fever of unknown origin and individuals in contact with rodents show positive test results for the HTNV antibody (Chandy et al, 2008).…”

Section: Asian-pacific Countriesmentioning

confidence: 99%

Hantavirus infection: a global zoonotic challenge

et al. 2017

View full text Add to dashboard Cite

Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide.

show abstract

“…There are reports of co-infections of Leptospira and Hantavirus infections in Sri Lanka [15]. Similarly co-infections could occur in these patients with various other infectious causes of acute pancreatitis i.e.…”

Section: Discussionmentioning

confidence: 98%

Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka

2016

View full text Add to dashboard Cite

BackgroundAcute pancreatitis is identified as an atypical and rare presentation of leptospirosis. In this report, we discuss a case series of severe leptospirosis with pancreatitis as a main complication during an unusual outbreak of leptospirosis in Anuradhapura district, Sri Lanka.Case presentationWe retrospectively reviewed clinical presentation, investigations, treatment and outcome of six confirmed cases of severe leptospirosis admitted to intensive care unit (ICU) of Teaching Hospital, Anuradhapura, within a three months period from November 2014 to January 2015.All six patients were previously healthy paddy farmers presented with fever, myalgia and arthralgia. Four patients had abdominal pain, nausea and vomiting on admission. Hypotension, Neutrophilic leukocytosis and thrombocytopaenia was detected in all patients in the initial stage. Four patients had serum amylase more than 900 (range 941–2420). All patients had acute kidney injury and hepatitis. Significantly elevated amylase and low serum calcium were present in 4 cases. Five patients recovered without any evidence of residual organ damage, but one succumbed to the illness.ConclusionThis case series emphasizes the importance of identification of acute pancreatitis as a common complication of Leptospirosis, in order to reduce mortality and morbidity.

show abstract

Concomitant leptospirosis-hantavirus co-infection in acute patients hospitalized in Sri Lanka: implications for a potentially worldwide underestimated problem

Cited by 34 publications

References 38 publications

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Hantavirus infection: a global zoonotic challenge

Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka

Contact Info

Product

Resources

About