Concomitant helminth infection downmodulates the Vaccinia virus-specific immune response and potentiates virus-associated pathology

Gazzinelli-Guimarães, Pedro Henrique; Freitas, Lorena Falabella Daher de; Gazzinelli-Guimarães, Ana Clara; Coelho, Fabiana Magalhães; Barbosa, Fernando Sérgio; Nogueira, Denise Silva; Amorim, Chiara Cássia Oliveira; Dhom-Lemos, Lucas de Carvalho; Oliveira, Luciana M.; Silveira, Alexandre Barcelos da; Fonseca, Flávio Guimarães da; Bueno, Lilian Lacerda; Fujiwara, Ricardo Toshio

doi:10.1016/j.ijpara.2016.08.007

Cited by 22 publications

(20 citation statements)

References 34 publications

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“…Traditionally, it has been shown that, beyond attenuating parasite-specific response, helminths can suppress the immunity to bystander pathogens or to vaccines 7 , 58 . It is known that the induction of the regulatory response by helminths is associated with the downmodulation of Th1 response 3 , 59 , 60 , considered crucial for the immunological control of viral, bacterial, or protozoal infections ( Figure 1 ). Immuno-epidemiological studies suggest that coincident infection with helminths has a strong potential to significantly influence the course of viral or protozoan infections, especially in those infections where protective immunity depends on a strong Th1/Th17 immune response 61 – 63 .…”

Section: Acuteness and Chronicity Of Infection Drive Distinct Immune mentioning

confidence: 99%

Helminth parasites and immune regulation

2018

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Helminth parasites are complex metazoans that belong to different taxonomic families but that collectively share the capacity to downregulate the host immune response directed toward themselves (parasite-specific immunoregulation). During long-standing chronic infection, these helminths appear able to suppress immune responses to bystander pathogens/antigens and atopic, autoimmune, and metabolic disorders. Helminth-induced immunoregulation occurs through the induction of regulatory T cells or Th2-type cells (or both). However, secreted or excreted parasite metabolites, proteins, or extracellular vesicles (or a combination of these) may also directly induce signaling pathways in host cells. Therefore, the focus of this review will be to highlight recent advances in understanding the immune responses to helminth infection, emphasizing the strategies/molecules and some of the mechanisms used by helminth parasites to modulate the immune response of their hosts.

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Section: Acuteness and Chronicity Of Infection Drive Distinct Immune mentioning

confidence: 99%

Helminth parasites and immune regulation

2018

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“…Helminth parasites are well known for their capacity to modulate the parasite-directed host immune response (1,2); with long-standing infection these parasites modulate the host response to bystander antigens/pathogens (3)(4)(5), to allergic diseases (6,7), and to both orally and parenterally administered vaccines (8,9). More controversially and largely on the basis of murine models, helminths have been implicated in ameliorating the severity of inflammatory bowel disease (10,11), diabetes (12,13), and arthritis (14), findings that have driven the concept of using these parasites or their excreted/secreted products, including their extracellular vesicles (15), for the treatment of inflammatory diseases (16,17).…”

Section: Introductionmentioning

confidence: 99%

Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development

Gazzinelli-Guimarães¹,

Prado²,

Ricciardi³

et al. 2019

Journal of Clinical Investigation

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“…In mice infected with Ascaris sp . and Vaccinia virus, where CD8 + T cell responses are critical for host protection, decreased frequencies of CD8 + T cells and an increase of mortality were detected [ 47 ]. For H .…”

Section: Discussionmentioning

confidence: 99%

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer

et al. 2017

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Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host’s immune response by releasing immunomodulatory molecules and inducing regulatory T cells (Tregs). This immunosuppressive state provoked in the host has been considered as a novel and promising approach to treat IBD patients and alleviate acute intestinal inflammation. On the contrary, specific parasite infections are well known to be directly linked to carcinogenesis. Whether a helminth infection interferes with the development of colitis-associated colon cancer (CAC) is not yet known. In the present study, we demonstrate that the treatment of mice with the intestinal helminth Heligmosomoides polygyrus at the onset of tumor progression in a mouse model of CAC does not alter tumor growth and distribution. In contrast, H. polygyrus infection in the early inflammatory phase of CAC strengthens the inflammatory response and significantly boosts tumor development. Here, H. polygyrus infection was accompanied by long-lasting alterations in the colonic immune cell compartment, with reduced frequencies of colonic CD8+ effector T cells. Moreover, H. polygyrus infection in the course of dextran sulfate sodium (DSS) mediated colitis significantly exacerbates intestinal inflammation by amplifying the release of colonic IL-6 and CXCL1. Thus, our findings indicate that the therapeutic application of helminths during CAC might have tumor-promoting effects and therefore should be well-considered.

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Concomitant helminth infection downmodulates the Vaccinia virus-specific immune response and potentiates virus-associated pathology

Cited by 22 publications

References 34 publications

Helminth parasites and immune regulation

Helminth parasites and immune regulation

Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer

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