Concomitant experimental coinfection by Plasmodium berghei NK65-NY and Ascaris suum downregulates the Ascaris-specific immune response and potentiates Ascaris-associated lung pathology

Vieira-Santos, Flaviane; Leal-Silva, Thaís; Padrão, Luiza de Lima Silva; Ruas, A.; Nogueira, Denise Silva; Kraemer, Lucas; Oliveira, Fabrício Marcus Silva; Caliari, Marcelo Vidigal; Russo, Remo Castro; Fujiwara, Ricardo Toshio; Bueno, Lilian Lacerda

doi:10.1186/s12936-021-03824-w

Cited by 7 publications

(1 citation statement)

References 72 publications

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“…However, simultaneous infection of mice with P. berghei and Ascaris suum eggs had no impact on P. berghei parasitemia. Instead, co-infection increased lung damage and mortality and was associated with the more rapid migration of A. suum larvae through the lungs into the airways (Vieira-Santos et al 2021).…”

Section: The Host Lensmentioning

confidence: 99%

Helminth-host-environment interactions: Looking down from the tip of the iceberg

Scott

2023

J. Helminthol.

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In 1978, the theory behind helminth parasites having the potential to regulate the abundance of their host populations was formalized based on the understanding that those helminth macroparasites that reduce survival or fecundity of the infected host population would be among the forces limiting unregulated host population growth. Now, 45 years later, a phenomenal breadth of factors that directly or indirectly affect the host–helminth interaction has emerged. Based largely on publications from the past 5 years, this review explores the host–helminth interaction from three lenses: the perspective of the helminth, the host, and the environment. What biotic and abiotic as well as social and intrinsic host factors affect helminths? What are the negative, and positive, implications for host populations and communities? What are the larger-scale implications of the host–helminth dynamic on the environment, and what evidence do we have that human-induced environmental change will modify this dynamic? The overwhelming message is that context is everything. Our understanding of second-, third-, and fourth-level interactions is extremely limited, and we are far from drawing generalizations about the myriad of microbe-helminth-host interactions.Yet the intricate, co-evolved balance and complexity of these interactions may provide a level of resilience in the face of global environmental change. Hopefully, this albeit limited compilation of recent research will spark new interdisciplinary studies, and application of the One Health approach to all helminth systems will generate new and testable conceptual frameworks that encompass our understanding of the host–helminth–environment triad.

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Section: The Host Lensmentioning

confidence: 99%

Helminth-host-environment interactions: Looking down from the tip of the iceberg

Scott

2023

J. Helminthol.

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The long-lasting Ascaris suum antigens in the lungs shapes the tissue adaptation modifying the pulmonary architecture and immune response after infection in mice

Oliveira,

Kraemer,

Vieira-Santos

et al. 2024

Microbial Pathogenesis

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Lessons from studying roundworm and whipworm in the mouse: common themes and unique features

Holland

Else

2021

Parasitology

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Ascaris lumbricoides, the roundworm, and Trichuris trichiura, the whipworm, are human intestinal nematode parasites; both are soil-transmitted helminths, are often placed together in an epidemiological context and both remain neglected despite high prevalence. Our understanding of parasitic disease continues to be enhanced through animal models. Despite the similarities between whipworm and roundworm, there are key differences between the two species and these have influenced the application of their respective animal models. In the case of T. trichiura, the fact that a murine equivalent, T. muris completes its life cycle in a mouse model has greatly enhanced our knowledge of whipworm biology, pathogenicity and immunology. In contrast, A. lumbricoides and its porcine equivalent, Ascaris suum, lack a rodent model in which the life cycle is completed. However, evidence continues to accumulate demonstrating that mice represent useful models of early Ascaris infection, a key stage of the life cycle. The use of mouse models for both Ascaris and Trichuris has a long history with early pioneers discovering fundamental aspects of each parasite's biology. Novel technologies and perspectives, as outlined in this special issue, demonstrate how through the prism of mouse models, we can continue to explore the similarities and differences between roundworms and whipworms.

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Concomitant experimental coinfection by Plasmodium berghei NK65-NY and Ascaris suum downregulates the Ascaris-specific immune response and potentiates Ascaris-associated lung pathology

Cited by 7 publications

References 72 publications

Helminth-host-environment interactions: Looking down from the tip of the iceberg

Helminth-host-environment interactions: Looking down from the tip of the iceberg

The long-lasting Ascaris suum antigens in the lungs shapes the tissue adaptation modifying the pulmonary architecture and immune response after infection in mice

Lessons from studying roundworm and whipworm in the mouse: common themes and unique features

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