Concomitant eosinophilia, fasciitis, and mycosis fungoides-like reaction with antinuclear autoantibodies in chronic myeloid leukaemia: role of a T-cell clone induced by imatinib

Jardin, Fabrice; Courville, Philippe; Lenain, Pascal; Pouplin, Sophie; Contentin, Nathalie; Lehembre, S. Duvert; Laquerrière, Annie; Clément, Jean‐François; Tilly, Hervé; Lenormand, Bernard

doi:10.1016/s1470-2045(05)70322-3

Cited by 8 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…100 In a second case, the eruption gradually disappeared over 2 months after cessation of treatment. 101 A case of follicular mucinosis developed on the face during imatinib therapy and was attributed to the drug. 102 Other rare eruptions include a pityriasis roseaelike eruption (4 cases), 103,104 biopsyconfirmed Sweet syndrome (2 cases), 105,106 a case of neutrophilic eccrine hidradenitis, 107 a case of eccrine squamous syringometaplasia, 108 and a case resembling papuloerythroderma of Ofuji.…”

Section: Multikinase Inhibitorsmentioning

confidence: 99%

Chemotherapeutic agents and the skin: An update

Heidary

Naik

Burgin

2008

Journal of the American Academy of Dermatology

222

138

View full text Add to dashboard Cite

Section: Multikinase Inhibitorsmentioning

confidence: 99%

Chemotherapeutic agents and the skin: An update

Heidary

Naik

Burgin

2008

Journal of the American Academy of Dermatology

222

138

View full text Add to dashboard Cite

“…There might be other factors related to pyomyositis aside from bacterial infection. Some cases of pyomyositis and fasciitis without bacterial infection have been described [ 4 , 5 ]. However, a case of pyomyositis associated with a surgical site has not been previously described (Table 1 ).…”

Section: Case Presentationmentioning

confidence: 99%

“…Common adverse effects of imatinib include edema, nausea, vomiting, diarrhea, muscle cramps, and cutaneous reactions, which are accompanied by emergence of a circulating T cell clone and autoantibodies against the nucleus. Jardin et al suggested that imatinib should be included in the group of pseudolymphoma-inducing drugs [ 5 ]. Edema and fluid retention are characteristic side effects of imatinib that possibly result from the alteration of interstitial fluid pressure control via the PDGF receptor [ 6 ].…”

Section: Case Presentationmentioning

confidence: 99%

Pyomyositis at the surgical site in a patient with chronic myeloid leukemia: a case report and literature review

et al. 2016

View full text Add to dashboard Cite

BackgroundPyomyositis is a rare, subacute, deep pyogenic infection of the muscle tissue. This disease has been previously described in patients that were immunocompromised due to a hematological malignancy.Case PresentationA 68-year-old man with a history of chronic myeloid leukemia was treated with imatinib. He was diagnosed with ascending colon cancer and underwent curative surgery. His postoperative course was uneventful, and he was healthy at 6 months after surgery, allowing for reinitiation of imatinib therapy. After the reinitiation of therapy, a computed tomography (CT) scan revealed a mass shadow in the right iliopsoas muscle. This lesion was clinically diagnosed as recurrent colon cancer with an abscess, which was resected surgically. A pathological examination uncovered both edema and inflammation. Two months after the second surgery, imatinib therapy was reinitiated; however, he again developed painful swelling and erythema in his right thigh. A CT scan revealed a similar shadow as described previously. He was then diagnosed with pyomyositis; he underwent incisional drainage and was administered linezolid. Following the treatment for pyomyositis, there was no cancer recurrence or evidence of any recurrent pyomyositis.ConclusionsFindings from this case suggest that both undergoing surgery and receiving imatinib therapy may modulate an individual’s immune response, whereby the surgical site becomes more prone to infection and may predispose an individual to pyomyositis. The case report is followed by a discussion of the literature regarding this disease, including potential risk factors and the underlying pathogenesis.

show abstract

“…3 Bekkenk et al 4 observed the occurrence of EBV-positive, primary, cutaneous, B-cell lymphoma during imatinib mesylate treatment that resolved after the therapy was discontinued. Common adverse effects include eosinophilia, fasciitis, and mycosis fungoides-like reactions.…”

Section: Commentmentioning

confidence: 99%

“…

Comment. 3 Very often NME precedes the onset of systemic symptoms and identifies the main pathologic process. In vitro studies have demonstrated that glucagon stimulates epidermal arachidonic acid synthesis 1 thus directly affecting the skin structures.

The cellular protein p62 (which is an adapter in signaltransducing pathways and a component of the inclusion bodies of various chronic degenerative disorders) is either absent from, or only focally expressed in, glucagonomas in contrast to its abundance in a wellfunctioning pancreas.

…”

mentioning

confidence: 99%