Concomitant diseases and their effect on disease prognosis in Meniere’s disease: diabetes mellitus identified as a negative prognostic factor

Pieskä, Teemu; Kotimäki, Jouko; Männikkö, Minna; Sorri, Martti; Hietikko, Elina

doi:10.1080/00016489.2017.1373850

Cited by 17 publications

(10 citation statements)

References 18 publications

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“…The relationship between metabolic disorder and MD has also been suggested. Previous studies have reported that DM is associated with severe hearing loss and frequent vertigo in cases of MD 9 and higher BMI and systolic BP are related to MD 10 . Therefore, the present study results are not consistent with those of previous studies.…”

Section: Discussionmentioning

confidence: 89%

“…MD is a complex heterogeneous disorder, with multiple factors reported to contribute to its development, 4 including age (older than 60 years), sex (female) 2 , 3 , genetics 5 , 6 , race (white people) 7 , stature and leg length (short) 8 , metabolic disorder 9 , 10 , autoimmunity 10 – 17 , anatomy 18 , allergies 19 , migraines 20 , weather (high humidity and low atmospheric pressure) 21 , diets, and stress 22 . However, the majority of studies are limited by a lack of population-based cohorts and low number of cases; therefore, the underlying disease pathological pathways remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Population-based study for the comorbidities and associated factors in Ménière’s disease

Kim

2022

Sci Rep

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To date, no study has reported the objective metabolic laboratory findings worldwide or the comorbidities for Ménière’s disease (MD) using a population-based design in Asian populations. The aim of this study was to investigate the comorbidities and associated factors for MD using the Korean National Health Insurance Service database. This retrospective population-based study was conducted using a data from the National Sample Cohort database from 2009 to 2015. We only enrolled patients whose records showed a prescription for MD medicine and audiometry findings as well as an appropriate diagnostic code. We also included a matched cohort without MD who were enrolled randomly and matched for sex, age, year of diagnosis, income level, and residential area with the MD group with a ratio of 10:1. We evaluated comorbidities including autoimmune, allergic, metabolic diseases and cancer and the health screening data including general characteristics (height, weight, waist circumference, body mass index, and blood pressure), laboratory findings (fasting glucose, cholesterol, triglyceride, high-density lipoproteintryglyceride (HDL) cholesterol, low-density lipoproteintryglyceride cholesterol, hemoglobin, creatinine, aspartate aminotransferase and alanine aminotransferase, and gamma-glutamyltrans- peptidase (rGT)), and general health behaviors (smoking, alcohol, and exercise) of the MD group, and compared these characteristics with those of the MD-free control group. A total of 2,013 and 20,130 participants were included in the MD and MD-free control groups (1,640 and 15,458 for health screening data). We found the increase in incidence of allergic rhinitis and allergic asthma, decrease in systolic blood pressure, HDL cholesterol, and rGT, and less frequent alcohol consumption and less prevalent smoking in the MD group. No significant differences were observed between the groups in the incidence of autoimmune diseases, and cerebro- and cardiovascular disease as well as health screening data and objective laboratory findings. Inconsistence with published studies, the results of this study suggest that the autoimmunity and metabolic disorder, and skeletal growth might not be associated with the onset of MD. Another well-designed study for other races will be needed to the generalization of this study results.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Population-based study for the comorbidities and associated factors in Ménière’s disease

Kim

2022

Sci Rep

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“…In addition, from 1998 to 2012, the prevalence of asthma, atopic dermatitis, and allergic rhinitis in the Korean adult population also increased from 1.2 to 3.1%, from 1.2 to 17.9%, and from 2.7 to 3.8%, respectively [Yoo et al, 2015;Kang et al, 2018]. These allergic diseases and diabetes have been demonstrated to be more frequent in patients with MD than in the general population [Derebery and Berliner, 2000;Tyrrell et al, 2014;Pieskä et al, 2018]. Further studies of the relationship between dietary and lifestyle changes and MD symptoms and its mechanisms would be needed to manage the symptoms of MD and control the incidence in Asian countries.…”

Section: Discussionmentioning

confidence: 96%

Epidemiology and Seasonal Variation of Ménière’s Disease: Data from a Population-Based Study

Kim

Cheon

2020

Audiol Neurotol

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Introduction: Ménière’s disease (MD) is a disease of the inner ear. In Asian countries, there is one previous epidemiologic study that used a retrospective survey of a specific district. Previous studies have demonstrated that weather variables are strongly associated with symptom aggravation in MD. However, no study has reported on seasonal variation of MD. Methods: We conducted a retrospective population-based study using the Korean national health insurance claims database (NHICD). In the present study, the prevalence and incidence of MD from 2013 to 2017 were calculated. Prevalence and incidence of MD according to sex, age group, and monthly incidence are presented. Seasonal incidence was calculated for four seasons. The seasonal average humidity and atmospheric pressure were also calculated. Results: The incidence rate of MD showed a rapid yearly increase from 2013 to 2017 in Korea. The prevalence and incidence rate by age group continued to increase up to the 70 year olds. The female-to-male ratio was 2.17. The seasonal incidence of MD was relatively high in summer and autumn and relatively low in winter and spring; however, there were no significant differences. Discussion/Conclusions: The rapid progression to an aging society, increase in medical accessibility, and lifestyle changes could be the reasons for the elevation of the incidence rate in the Korean population. Consistent with a previous study, the incidence of MD was higher in seasons with high humidity and low atmospheric pressure; however, there were no significant differences. Further studies about the relationship between diet and MD, seasonality of MD with long-term analysis, and investigating the underlying mechanisms connecting weather and MD are needed.

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“…All domains of the Cochrane Risk of Bias tool for RCTs will be considered, including selection bias (sequence generation and allocation sequence concealment), performance bias (blinding of participants and personnel), detection bias (blinding of outcome assessment), attrition bias (incomplete outcome data), reporting bias (selective reporting), and other biases considered relevant to the review topic. We will also evaluate baseline imbalances between groups with respect to comorbidities and factors that may impact our outcomes of interest, including history of falls more than once in the past year, older age, white race, female sex, higher BMI, current tinnitus, prior therapies received, allergies, immune dysfunction (e.g., ankylosing spondylitis, systemic lupus erythematosus, psoriasis), autonomic dysfunction, poor mental health [18, 20, 22], arthritis [23], history of hearing loss or episodic vertigo [24], familial history of MD, and diabetes mellitus [25].…”

Section: Methodsmentioning

confidence: 99%

Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis

et al. 2019

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BackgroundHearing loss is one of the leading causes of disability in Canada and worldwide, with more than one million Canadians enduring a hearing-related disability. Meniere’s disease (MD) is a chronic condition of the inner ear, manifesting as a triad of disabling symptoms, including attacks of vertigo, fluctuating sensorineural hearing loss (SNHL), and tinnitus. Impacts on quality of life are severe, particularly with respect to restrictions in social participation and physical activity, fatigue, and reduced capacity to work. Anxiety and other psychological disorders may result from the restrictions imposed on life, the constant uncertainty of vertigo attacks, and fluctuating SNHL, with neuroses and depression affecting 40 to 60% of sufferers of intractable MD. There is a need to establish the benefits of previously studied interventions with greater certainty. The planned systematic review and meta-analyses/network meta-analyses (NMAs) will assess the relative effects of competing pharmacologic and surgical interventions for management of MD in adults.MethodsAn experienced medical information specialist in consultation with the review team will develop the electronic search strategies. We will search various databases including MEDLINE, Embase, and the Cochrane Library with no date or language restrictions for published literature, and key clinical trial registries for in-progress and completed trials. Screening of the literature will be performed by two reviewers independently using pre-specified eligibility criteria, and quality of the included studies will be assessed using the Cochrane Risk of Bias tool. We will resolve disagreements through consensus or third-party adjudication. When applicable, meta-analyses and NMAs will be pursued to compare interventions in terms of their effects on outcomes, including frequency and severity of vertigo, occurrence and intensity of tinnitus, changes in hearing and speech recognition, quality of life, and harms. Separate analyses exploring the effects of pharmacologic and surgical approaches will be performed.DiscussionOur planned systematic review will provide informative evaluations of existing treatments for management of Meniere’s disease. The findings will inform practitioners as to the relative benefits and harms of the existing competing interventions for MD, offer optimal clinical treatment strategies, identify evidence gaps, and determine promising therapies for evaluation in future trials.Systematic review registrationPROSPERO CRD42019119129

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Concomitant diseases and their effect on disease prognosis in Meniere’s disease: diabetes mellitus identified as a negative prognostic factor

Abstract: A patient's concomitant diseases, especially diabetes, should be treated effectively because they might affect the progression of MD. Further studies on the effects of concomitant diseases on MD prognosis are needed.

Cited by 17 publications

References 18 publications

Population-based study for the comorbidities and associated factors in Ménière’s disease

Population-based study for the comorbidities and associated factors in Ménière’s disease

Epidemiology and Seasonal Variation of Ménière’s Disease: Data from a Population-Based Study

Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis

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