Concomitant contact‐allergic reactions to iodopropynyl butylcarbamate and iodine

Vanhoutte, Charlotte; Goossens, An; Gilissen, Liesbeth; Huygens, Sarah; Vital-Durand, D; Dendooven, Ella; Aerts, Olivier

doi:10.1111/cod.13224

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…However, other studies found a lower sensitization prevalence (eg, 0.53%) 57 . IPBC liberates iodine, which has also been supported by observing simultaneous contact allergy to IPBC and iodine 58 . Owing to possible endocrine interference, use concentrations are restricted to between 0.02% in rinse‐off products and 0.0075% in deodorants/antiperspirants for many years (SCCNFP/0826/04, EU Cosmetics Regulation, Annex V/56).…”

Section: Discussionmentioning

confidence: 93%

“…57 IPBC liberates iodine, which has also been supported by observing simultaneous contact allergy to IPBC and iodine. 58 Owing to possible endocrine interference, use concentrations are restricted to between 0.02% in rinse-off products and 0.0075% in deodorants/antiperspirants for many years (SCCNFP/0826/04, EU Cosmetics Regulation, Annex V/56). It would be of interest to further investigate IPBC regarding the clinical relevance of (weak) positive patch test reactions.…”

Section: Additional Consecutively Tested Allergensmentioning

confidence: 99%

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Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

et al. 2020

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Background Clinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series. Objectives To present current results from the European Surveillance System on Contact Allergies, including 13 countries represented by 1 to 11 departments. Methods Anonymized or pseudonymized patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control. Results In the 4 years (2015‐2018), data from 51 914 patients patch tested with the European baseline series (EBS) of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%), and Myroxylon pereirae resin (balsam of Peru; 5.8%). Conclusions While the prevalence of MI contact allergy decreased substantially following regulatory intervention, the persistently high levels of allergy to metals, fragrances, other preservatives, and rubber chemicals point to problems needing further research and, potentially, preventive efforts. Results with national additions to the baseline series provide important information on substances possibly to be considered for inclusion in the EBS.

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Section: Discussionmentioning

confidence: 93%

Section: Additional Consecutively Tested Allergensmentioning

confidence: 99%

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

et al. 2020

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“…In the case of iodopropynyl butylcarbamate (IPBC), it is iodine liberation and systemic availability that led the EU to limit the use concentration to 0.02% in rinse-off, 0.01% in leave-on cosmetics and 0.0075% in deodorants, see (EC) No 1223/2009. The recent observation of frequent concomitant allergic reactions to IPBC and iodine [340] supports this cautionary approach, pointing to a relevant co-exposure to both IPBC, which is a contact allergen in its own right [341], and (liberated) iodine.…”

Section: Allergen-specific Aspectsmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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“…1223/2009. Der aktuelle Bericht über häufige konkomitante allergische Reaktionen auf IPBC und Iod [340] untermauert diesen vorsichtigen Ansatz und deutet auf eine relevante Koexposition gegenüber IPBC als eigenständigem Kontaktallergen [341] und (freigesetztem) Iod hin.…”

Section: Diskussionunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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Concomitant contact‐allergic reactions to iodopropynyl butylcarbamate and iodine

Cited by 9 publications

References 9 publications

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

Contact Allergy—Emerging Allergens and Public Health Impact

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

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