Concomitant autoimmunity in myasthenia gravis — Lack of association with IgA deficiency

Abstract

A marked increase in concomitant autoimmune diseases has previously been noted in patients with myasthenia gravis (MG). We show that these diseases occur both before and after the onset of MG and that the process is not influenced by thymectomy. IgA deficiency (IgAD), which is strongly associated with the same HLA haplotype as early onset MG, has recently been suggested to be an autoimmune disease. However, there was no increase in the prevalence of IgAD in a large cohort of Swedish MG patients.

Protective Effect of TRPV1 against Renal Fibrosis via Inhibition of TGF-β/Smad Signaling in DOCA-Salt Hypertension

“…Two IgAD individuals were identified (P = 0.19) (14). Combined with previous studies, 5 of 1,107 D 1 7 ( 1 1 -1 2 ) 1 3 8 3 -1 3 9 6 , N …”

Selective IgA Deficiency in Autoimmune Diseases

“…In summary, IgAD is markedly more prevalent in patients with a variety, albeit not all (such as MG [14]), of 8.1 haplotype-associated autoimmune diseases. Similarities in the genetic susceptibility suggest involvement of common pathophysiological pathways, implicating that IgAD, as recently suggested by Ferreira et al (13), may in fact be an autoimmune disease.…”

“…A common genetic background for selected autoimmune disorders, such as GD, SLE, T1D, CD and potentially MG and RA, involving both MHC and non-MHC encoded genes, has previously been suggested (14,168). There is also a considerable overlap in concomitant diseases; for example, T1D is prevalent in patients with GD, SLE, CD and RA.…”

“…Other haplotypes, including HLA-DR7, DQ2 and DR1, DQ5 are also associated with IgAD (11). In contrast, the DR15, DQ6 haplotype has been shown to confer an almost complete protection against the disorder (12)(13)(14). Polymorphisms in the non-MHC genes interferoninduced helicase 1 (IFIH1) and c-type lectin domain family 16, member A (CLEC16A) genes have also been shown to be associated with IgAD in a recent genome-wide association study (GWAS) (13).…”

Myasthenia Gravis and Stroke in the Setting of Giant Cell Arteritis

“…Several clinical observations support the idea that a general derangement of the immune system regulation plays an important role in the pathophysiology of MG. MG has been reported to be associated with a number of autoimmune disorders including more frequently rheumatoid arthritis [4], Graves' disease [4, 5], and systemic lupus erythematosus [6] but also Type I diabetes [5]. Moreover, similar genetic associations, overlapping with other autoimmune conditions, including the HLA-B8, DR3 haplotypes and the R620W variants of PTPN22 have been demonstrated in the case of MG [7]. Finally, patients with MG demonstrate a therapeutic response to various immunomodulating therapies, immunosuppressants, and thymectomy [8].…”