Concomitant alterations of metabolic parameters, cardiovascular risk factors and altered cortisol secretion in patients with adrenal incidentalomas during prolonged follow‐up

Abstract

New-onset ACS developed in 31% patients with NFAI, whereas 21% of NFAI patients had H-UFC levels. All AI patients as a group and the subgroups of N-UFC, H-UFC, C-ACS and ACS patients developed deterioration of metabolic parameters during follow-up that was more prominent in ACS patients.

Nonfunctioning adrenal incidentaloma: A novel predictive factor for metabolic syndrome

“…Despite the growing number of studies evidencing a higher frequency of these isolated components of metabolic syndrome in the NFAI population, [18][19][20][21][22][23] it has been assumed this is the first clinical study to evaluate and classify patients with NFAI by different Some studies have also demonstrated higher frequencies of metabolic syndrome components in NFAI patients. [18][19][20][21][22][23] In this context, our results are in line with previous reports, which have demonstrated increased frequency of glucose and lipid disturbances and arterial hypertension. In a multicenter urban Brazilian population study, the prediabetes rate in the 60-to 69-year-old group was 11.2%.…”

“…In the present study, patients with NFAI presented a higher frequency of all criteria for metabolic syndrome (hypertension, hyperglycaemia, dyslipidaemia, increased waist circumference) and a greater metabolic syndrome frequency by four different classifications compared to controls. Despite the growing number of studies evidencing a higher frequency of these isolated components of metabolic syndrome in the NFAI population, it has been assumed this is the first clinical study to evaluate and classify patients with NFAI by different metabolic syndrome criteria defined by globally recognized institutions, and to compare them to controls with normal adrenal imaging.…”

“…There is a large body of studies demonstrating that ACS patients present with higher metabolic disorders frequency caused by excess cortisol . Regarding NFAI, its definition includes absence of hypercortisolism as well as any other relevant hormonal activity and the guidelines do not indicate extra care.…”

“…There is a large body of studies demonstrating that ACS patients present with higher metabolic disorders frequency caused by excess cortisol. 5,20,[33][34][35][36][37] Regarding NFAI, its definition includes absence of and their levels usually increase with obesity. 39,40 In agreement, our study demonstrated that even both groups having comparable BMI the signs of insulin resistance were significantly higher in the NFAI group, which might point to a probable difference in the quality of the adipose tissue of these patients or higher circulating levels of me-…”

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

“…Zelinka et al showed that pheochromocytoma was associated with endothelial dysfunctions and, established further atherosclerosis (23). However; previous studies reported that nonfunctional adrenal adenoma was associated with an increased cardio-metabolic disturbance (30) including hypertension (31), insulin resistance or diabetes (12,17). Nonfunctional adrenal adenomas have shown to be associated with increased risk of cardiovascular events (17), and mortality (14).…”