2011
DOI: 10.1016/j.clon.2010.09.004
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Concomitant Adjuvant Chemoradiotherapy with Weekly Low-dose Cisplatin for High-risk Squamous Cell Carcinoma of the Head and Neck: a Phase II Prospective Trial

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Cited by 38 publications
(23 citation statements)
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“…Nine single-arm studies evaluated the efficacy of adjuvant CRT. [23][24][25][26][27][28][29][30][31] Of these, six were prospective trials. 23,24,26,28,30,31 Data gathered in these studies covered a period from 1980 to 2009.…”
Section: Literature Search Resultsmentioning
confidence: 99%
“…Nine single-arm studies evaluated the efficacy of adjuvant CRT. [23][24][25][26][27][28][29][30][31] Of these, six were prospective trials. 23,24,26,28,30,31 Data gathered in these studies covered a period from 1980 to 2009.…”
Section: Literature Search Resultsmentioning
confidence: 99%
“…Radiotherapy (RT) is a standard of care for head and neck cancer (HNC) patients in both the definitive and postoperative settings [1,2]. Combined modality treatment including RT and chemotherapy (CT) and/or bio-therapy is a well-established option providing a survival advantage over radiation alone [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…CDDP is expected to have a radiosensitizing effect when it is administered every week during radiation therapy and the dose intensity of weekly CDDP (40 mg/m 2 /week) is higher than that of 3-weekly CDDP (33 mg/m 2 /week). In fact, promising results of post-operative weekly CDDP þ RT were reported in two prospective trials (5,6). In addition, weekly CDDP þ RT has several advantages over 3-weekly CDDP þ RT in terms of safety and toxicity.…”
Section: Introductionmentioning
confidence: 90%