Conclusion

Nelson, Byron

doi:10.4324/9781003217282-7

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 41 ] This is the case when the compression energy is distinctly larger than the bending energy at similar displacements of the boundaries. [ 75 ] In nature, tissue layers are often connected to a substrate, i.e., a thicker layer with different mechanical properties. Depending on the properties of the layers (e.g., Young's moduli, adhesion to the substrate) [ 76 ] and by introducing in‐plane mechanical mismatch strain, a single buckle or multiple wrinkles may occur.…”

Section: Curvature Emergence In Biologymentioning

confidence: 99%

“…Typical wrinkles form periodic wavy patterns with wavelengths and amplitudes depending on the ratio of Young's moduli, the Poisson's ratios, and the thickness of the tissue layer. [ 75 ] Single‐layer systems can also develop 3D shapes through buckling. For example, beet leaves present remarkable similarities between their outer edge, where deformation may be induced by heterogenous cell growth/division rates (Figure 7g, lower panel), and the edge of a torn plastic sheet, where plastic deformation occurs during pulling while regions further away from the edge are deformed elastically (Figure 7g, upper panel).…”

Section: Curvature Emergence In Biologymentioning

confidence: 99%

See 1 more Smart Citation

Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales

et al. 2023

View full text Add to dashboard Cite

Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology has been supported by numerous recent experimental and theoretical investigations in recent years. In this review, we first give a brief introduction to the key ideas of surface curvature in the context of biological systems and discuss the challenges that arise when measuring surface curvature. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, we address the interplay between the distribution of morphogens or micro-organisms and the emergence of curvature across length scales with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by-product of the chemical, biological and mechanical processes but that curvature acts also as a signal that co-determines these processes.

show abstract

Section: Curvature Emergence In Biologymentioning

confidence: 99%

Section: Curvature Emergence In Biologymentioning

confidence: 99%

Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In general, mechanical processes such as folding or buckling lead to complex folded and branched structures in our organs, such as in the lung, kidney, brain, intestines, or circulatory system. [ 185 ] The remarkable degree of self‐organization, cooperation, and synchronization across individual cells in a multicellular mechanical network has led to the paradigm that certain cell collectives behave as higher‐ordered “supracells”. [ 186–189 ] Spatial induction of fate‐determinants, [ 190,191 ] nonlinear interactions between individual cells or the ECM, [ 192,193 ] and cell‐to‐cell variability [ 194,195 ] enable symmetry breaking and pattern formation from a previously unspecified and homogenous population of cells.…”

Section: Cell Collectives and Monolayersmentioning

confidence: 99%

Cell Shape and Forces in Elastic and Structured Environments: From Single Cells to Organoids

Link

Weißenbruch

Tanaka

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

With the advent of mechanobiology, cell shape and forces have emerged as essential elements of cell behavior and fate, in addition to biochemical factors such as growth factors. Cell shape and forces are intrinsically linked to the physical properties of the environment. Extracellular stiffness guides migration of single cells and collectives as well as differentiation and developmental processes. In confined environments, cell division patterns are altered, cell death or extrusion might be initiated, and other modes of cell migration become possible. Tools from materials science such as adhesive micropatterning of soft elastic substrates or direct laser writing of 3D scaffolds have been established to control and quantify cell shape and forces in structured environments. Herein, a review is given on recent experimental and modeling advances in this field, which currently moves from single cells to cell collectives and tissue. A very exciting avenue is the combination of organoids with structured environments, because this will allow one to achieve organotypic function in a controlled setting well suited for long‐term and high‐throughput culture.

show abstract

Conclusion

Cited by 2 publications

References 0 publications

Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales

Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales

Cell Shape and Forces in Elastic and Structured Environments: From Single Cells to Organoids

Contact Info

Product

Resources

About