Concluding remarks: discussion on natural and artificial enzymes including synthetic models

Abstract

This paper overviews the final remarks lecture delivered (by K. D. K.) at the end of this bioinorganic chemistry Faraday Discussion, held online for a worldwide audience from January 31 – February 3, 2022.

Coordination Variations within Binuclear Copper Dioxygen-Derived (Hydro)Peroxo and Superoxo Species; Influences upon Thermodynamic and Electronic Properties

“…The synthesis and detailed characterization of dioxygen-derived complexes, ligand(s)–Cu n –(X) (X = O 2 •– , O 2 2– , –OOH), has been of considerable ongoing interest in the last 30 years and continue to challenge synthetic bioinorganic communities ,,, Copper bound peroxo, hydroperoxo, and superoxo species occur widely in biochemistry, as mentioned in the introduction for Hc and Ty but also in other copper monooxygenases, amine and galactose oxidases, and Cu/Zn superoxide dismutase. , Hydroperoxo-copper chemistries (as a ligand–copper complex or copper­(II) salt with H 2 O 2 ) are also frequently utilized in organic compound oxidations. , A detailed understanding of the properties, reactivities, and thermodynamic interrelationships of these transient intermediates is necessary to advance our knowledge concerning copper (and other metal ions) processing of O 2 in chemistry and biology.…”