Concluding Remarks

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

“…Typically, initially, the intraepidermal component extends laterally for more than three rete ridges past the confines of the dermal component [38]. Neoplastic melanocytes became progressively larger and often of epithelioid morphology and are arranged in either single units or atypical nests [2]. Viros et al found that an increased upward scatter and nest formation of intraepidermal melanocytes in the RGP portion of the tumors, thickening of the involved epidermis, sharp demarcation from the surrounding skin, as well as the presence of a larger, rounder, and more pigmented tumor cells were distinguishing features of melanomas with BRAF mutation and tend to occur in the skin without marked solar elastosis in anatomic sites such as the trunk.…”

“…Dermoscopy is a non-invasive, in vivo technique that allows the visualization of subsurface skin structures in the epidermis, at the dermoepidermal junction, and in the upper dermis; these structures are usually not visible to the naked eye [1][2][3]. Dermoscopy improves the diagnosis of melanocytic lesions in clinical practice, improves the confidence in the diagnosis of benign pigmented lesions, also reducing the number of unnecessary biopsies [1][2][3]. Several meta-analyses proved that dermoscopy increases the sensitivity for the diagnosis of melanoma without decreasing the specificity, compared with the naked-eye examination [1][2][3].…”

“…Dermoscopy improves the diagnosis of melanocytic lesions in clinical practice, improves the confidence in the diagnosis of benign pigmented lesions, also reducing the number of unnecessary biopsies [1][2][3]. Several meta-analyses proved that dermoscopy increases the sensitivity for the diagnosis of melanoma without decreasing the specificity, compared with the naked-eye examination [1][2][3].…”