Abstract:A concise and convergent stereoselective synthesis of Curvulone B is described. The synthesis utilized the tandem isomerization followed by C-O and C-C bond forming reaction following Mukaiyama-type aldol conditions for the construction of trans-2,6-disubstituted dihydropyran ring system as the key step. Other important features of this synthesis are cross-metathesis, epimerization and Friedel-Crafts acylation reaction.
“…They are isolated from the known sea-water algal species i.e., Gracilaria folifera. 145 Considering the utility of the curvulone type natural product, Banoth et al 146 in 2020 carried out a brief and efficient total synthesis of curvulone by utilizing the Mukaiyama aldol reaction as one of its key steps. For this purpose, homoallylalcohol 335 was reacted with acrolein and Hoveyda Grubbs II reagent in dichloromethane to obtain unsaturated aldehyde 336 in 87% yield.…”
Section: Synthesis Of Miscellaneous Natural Productsmentioning
Mukaiyama aldol reaction results in the highly enantioselective and diastereoselective synthesis of β-hydroxy carbonyls. Here, total syntheses of some natural products via this reaction as a key step have been presented.
“…They are isolated from the known sea-water algal species i.e., Gracilaria folifera. 145 Considering the utility of the curvulone type natural product, Banoth et al 146 in 2020 carried out a brief and efficient total synthesis of curvulone by utilizing the Mukaiyama aldol reaction as one of its key steps. For this purpose, homoallylalcohol 335 was reacted with acrolein and Hoveyda Grubbs II reagent in dichloromethane to obtain unsaturated aldehyde 336 in 87% yield.…”
Section: Synthesis Of Miscellaneous Natural Productsmentioning
Mukaiyama aldol reaction results in the highly enantioselective and diastereoselective synthesis of β-hydroxy carbonyls. Here, total syntheses of some natural products via this reaction as a key step have been presented.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.