Concise syntheses and some biological activities of <scp>dl</scp>‐2,5‐di‐O‐methyl‐chiro‐inositol, <scp>dl</scp>‐1,4‐di‐O‐methyl‐scyllo‐inositol, and <scp>dl</scp>‐1,6‐dibromo‐1,6‐dideoxy‐2,5‐di‐O‐methyl‐chiro‐inositol

Aksu, Kadir; Akıncıoğlu, Hülya; Gülçın, İlhami; Kelebekli, Latif

doi:10.1002/ardp.202000254

Cited by 7 publications

(3 citation statements)

References 88 publications

(147 reference statements)

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“…When the results are compared, unlike CA isoenzyme inhibition profiles, dibromo[1‐{(4‐hydroxyphenyl)ethyl}‐3‐(4‐methylbenzyl)benzimidazol‐2‐ylidene]pyridine palladium(II) ( 1d ) demonstrated the most active inhibition ability toward hCA I and II isoenzyme. It is well‐known that the presence of bromo, [ 63,64 ] phenyl, [ 65 ] benzyl, [ 28 ] pyridine, [ 66 ] and imidazole [ 67 ] groups in the molecules has favor of effects on increasing inhibition effect of AChE and BChE enzymes.…”

Section: Resultsmentioning

confidence: 99%

“…[62] The K i values of the test complexes demonstrated that the most active compound against AChE and BChE was complex 1d (AChE, It is standard for α-Glu with values of it taken from Tariq et al [48] and Klochkov et al [49] are compared, unlike CA isoenzyme inhibition profiles, dibromo[1-{(4hydroxyphenyl)ethyl}-3-(4-methylbenzyl)benzimidazol-2-ylidene] pyridine palladium(II) (1d) demonstrated the most active inhibition ability toward hCA I and II isoenzyme. It is well-known that the presence of bromo, [63,64] phenyl, [65] benzyl, [28] pyridine, [66] and imidazole [67] groups in the molecules has favor of effects on increasing inhibition effect of AChE and BChE enzymes.…”

Section: Enzyme Inhibition Resultsmentioning

confidence: 99%

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New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

Behçet

Taslimi

Gök

et al. 2022

Archiv der Pharmazie

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Five 4‐hydroxyphenylethyl substituted pyridine enhanced, precatalyst, preparation, stabilization, and initiation‐Pd‐N‐heterocyclic carbene (PEPPSI‐Pd‐NHC) complexes are synthesized in a straightforward way. All PEPPSI‐Pd‐NHC complexes were prepared by mixing 4‐hydroxyphenylethyl substituted NHC precursors, palladium chloride, potassium carbonate, and potassium bromide in pyridine. All complexes were screened for human carbonic anhydrase I (hCA I) and hCA II, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glucosidase (α‐Glu) inhibitory activities. The ChE inhibitory activities of the new PEPPSI‐Pd‐NHC complexes bearing the 4‐hydroxyphenylethyl group (1a–e) against α‐Glu, AChE, and BChE were determined by the Tao and Ellman methods. The results indicated that all the synthetic complexes exhibited potent inhibitory activities against all targets as compared to the standard inhibitors, revealed by IC50 values. The Ki values of the new PEPPSI‐Pd‐NHC complexes 1a–e for hCA I, hCA II, AChE, BChE, and α‐Glu were obtained in the ranges of 18.98–32.65, 22.95–38.13, 3.67–11.65, 4.09–9.36, 186.92–287.45 µM, respectively. Among the synthesized complexes, the most potent complexes were 1c toward hCA I and II with Ki values 18.98 and 22.95 µM, and 1d toward AChE and BChE with Ki = 3.67 and 4.09 µM, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Enzyme Inhibition Resultsmentioning

confidence: 99%

New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

Behçet

Taslimi

Gök

et al. 2022

Archiv der Pharmazie

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“…Methylinositol has been used in trials to study the treatment of dementia and Alzheimer's disease [50] .…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of co-disease genes between COVID-19 and osteoarthritis

Zhang,

Liu,

et al. 2024

Preprint

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Background: The molecular mechanisms of corona virus disease 2019 (COVID-19) and osteoarthritis (OA) are unclear, and there is an urgent need to identify new biomarkers and explore their potential molecular mechanisms in COVID-19 and OA. Methods: The GSE57218, GSE157103 training sets and the GSE82107, GSE171110 validation sets were acquired via gene expression omnibus (GEO) database. First, differentially expressed genes (DEGs) between disease and normal samples in the GSE57218 and GSE157103 training sets were respectively sifted out by differential expression analysis. The modules with the highest correlation with OA and normal, COVID-19 and non COVID-19 were gained by weighted gene co-expression network analysis (WGCNA), individually. Then, OA-DEGs were intersected with the module genes that had significant correlation with OA, and COVID-19-DEGs were intersected with the module genes which were dramatically correlated with COVID-19 to yield OA-intersected genes and COVID-19 intersected genes, respectively. The OA-intersected genes and COVID-19 intersected genes were intersected to yield candidate genes, and they were analyzed for function enrichment analysis. Next, the seven algorithms (Closeness, MCC, Degree, MNC, Radality, Stress and EPC) were performed on candidate genes to sift out biomarkers. Finally, we constructed the competing endogenous RNA (ceRNA), transcription factor (TF)/miRNA-mRNA and drug-target regulatory networks. Results:There were 1135 OA-DEGs and 4336 COVID-19-DEGs between disease and normal samples in the GSE57218 and GSE157103 training sets, respectively. The pink, blue and brown modules had significant correlations with OA in the GSE57218 training set, while in the GSE157103 training set, the pink and brown modules were notably correlated with COVID-19. We finally yield 715 OA-intersected genes and 2282 COVID-19-intersected genes. After intersecting the above two intersected genes, we gained 106 candidate genes, and they were involved in ADP metabolic process, nucleoside diphosphate phosphorylation, etc.. The 7 biomarkers, namely AK1, APP, ENO1, TPI1, HSP90B1, HSPB1 and ESR1, were acquired based on seven algorithms. Finally, we successfully constructed the ceRNA, TF/miRNA-mRNA and drug-target networks. Conclusion: Through bioinformatic methods, we explored the biomarkers (AK1, APP, ENO1, TPI1, HSP90B1, HSPB1 and ESR1) of COVID-19 combined OA, providing new ideas for studies related to molecular mechanisms and treatment of comorbidity.

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Synthesis and biological effects evaluation of benzoconduritols C and D from oxabenzonorbornadiene

et al. 2021

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Concise syntheses and some biological activities of dl‐2,5‐di‐O‐methyl‐chiro‐inositol, dl‐1,4‐di‐O‐methyl‐scyllo‐inositol, and dl‐1,6‐dibromo‐1,6‐dideoxy‐2,5‐di‐O‐methyl‐chiro‐inositol

Cited by 7 publications

References 88 publications

New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

Identification and analysis of co-disease genes between COVID-19 and osteoarthritis

Synthesis and biological effects evaluation of benzoconduritols C and D from oxabenzonorbornadiene

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