2018
DOI: 10.1002/sctm.17-0210
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Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease

Abstract: The capacity of stem and progenitor cells to stimulate cardiac regeneration has been studied for almost 20 years, with very promising preclinical data and mixed clinical results. Several cell types have been studied, identified by their cell surface markers, differentiation capacity and their secreted growth factors. Bone marrow derived mesenchymal stem cells (MSCs) have been found to have potent regenerative capacity, through multiple mechanisms, including mesoderm lineage differentiation, immunomodulation, a… Show more

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Cited by 89 publications
(75 citation statements)
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“…Mesenchymal stem cells (MSCs), which have been isolated from bone marrow, umbilical cord, dental pulp, and a diversity of other tissues, have the ability of differentiating into tissue‐specific lineages . An increasing number of studies have demonstrated promising applications of MSCs in regenerative medicine and tissue engineering to repair and regenerate damaged or lost tissues due to diseases and traumatic injuries and, nonetheless, translational uses of MSCs remain inefficacious, in part due to their limited capability of migrating and homing . Thus, gaining insights into the mechanisms regulating MSC migration can provide useful information for developing novel strategies to prepare MSCs for clinical applications and improve the efficacy of MSC‐based therapies as well as evolving a better understanding of the contentious MSC biology .…”
Section: Introductionmentioning
confidence: 99%
“…Mesenchymal stem cells (MSCs), which have been isolated from bone marrow, umbilical cord, dental pulp, and a diversity of other tissues, have the ability of differentiating into tissue‐specific lineages . An increasing number of studies have demonstrated promising applications of MSCs in regenerative medicine and tissue engineering to repair and regenerate damaged or lost tissues due to diseases and traumatic injuries and, nonetheless, translational uses of MSCs remain inefficacious, in part due to their limited capability of migrating and homing . Thus, gaining insights into the mechanisms regulating MSC migration can provide useful information for developing novel strategies to prepare MSCs for clinical applications and improve the efficacy of MSC‐based therapies as well as evolving a better understanding of the contentious MSC biology .…”
Section: Introductionmentioning
confidence: 99%
“…Bone marrow-derived mesenchymal stem cells (MSCs) are a promising cell source for such cellular therapy because of their ability for self-renewal, multipotency and immunosuppressive properties. 2 Bone marrow MSCs are commonly thought to reside in hypoxic niches in the bone marrow, important for maintaining their undifferentiated state. 3 This suggests that oxygen tension plays an important role in stem cell regulation and indeed oxygen tension was recently found to affect MSC differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…Human MSCs or other progenitor cells are currently being tested in multiple clinical trials for a variety of indications . For acute trauma in otherwise healthy individuals, the need is temporary, and persistence of administered cells may not be required.…”
Section: Discussionmentioning
confidence: 99%
“…Human MSCs or other progenitor cells are currently being tested in multiple clinical trials for a variety of indications. [12][13][14] For acute trauma in otherwise healthy individuals, the need is temporary, and persistence of administered cells may not be required. MSCs are primary cells derived from adult tissue without genetic modification, reducing the risk of mutation or tumorigenesis.…”
Section: Discussionmentioning
confidence: 99%