Concise review: Current understanding of extracellular vesicles to treat neuropathic pain

Zhang, Kexin; Li, Pei; Jia, Yuanyuan; Liu, Ming; Jiang, Jingjing

doi:10.3389/fnagi.2023.1131536

Cited by 4 publications

(2 citation statements)

References 119 publications

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“…Exosomes are not only involved in the normal physiological mechanisms of pain but also contribute to the development of chronic pain [7,22,23]. Unraveling the intricate details of exosome formation, cargo modification, and release in various chronic pain conditions requires dedicated research efforts.…”

Section: Extracellular Vesicles (Evs)mentioning

confidence: 99%

Contribution of Small Extracellular Vesicles from Schwann Cells and Satellite Glial Cells to Pain Processing

Gazerani

2024

Neuroglia

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Extracellular vesicles (EVs), including exosomes and microvesicles, are membrane-bound particles released by cells into extracellular space. These vesicles carry various molecules, such as proteins and lipids, and can serve as mediators of intercellular communication. EVs have been implicated in the communication between different cell types in the nervous system, for instance, the neurons and glial cells of the central nervous system (CNS) and peripheral nervous system (PNS). Satellite glial cells (SGCs) surround and support neurons in the sensory ganglia of the PNS, and it has been proposed that the EVs released by SGCs may contribute to the processing of pain-related signals and features. This includes the modulation of neuronal activity, the release of pro-inflammatory signaling molecules, and sensitization. A noticeable finding is that EVs can transfer bioactive molecules, including proteins and microRNAs (miRNAs), between cells, influencing cellular functions such as gene expression regulation involved in the transmission and modulation of pain signals. Schwann cells (SCs) also release EVs. SC-derived EVs sequester TNFR1, influencing TNFα activity and regulating neuroinflammation in peripheral nerve injuries. Understanding peripheral glia’s EVs role in pain processing is an emerging area in neuroscience. Here, the latest findings, challenges, and potential are presented to encourage future research.

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Section: Extracellular Vesicles (Evs)mentioning

confidence: 99%

Contribution of Small Extracellular Vesicles from Schwann Cells and Satellite Glial Cells to Pain Processing

Gazerani

2024

Neuroglia

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“…Neuropathic pain is a type of chronic pain that occurs following an injury or disease in the peripheral nervous system [124], and appears to be related to neuroinflammation [125,126]. Various clinical studies have shown that exosomes can improve neuropathic pain by reducing proinflammatory cytokines, promoting vascular regeneration, promoting neuronal proliferation and function by axonal regrowth and Schwann cell activation [127,128], which contribute to providing a favorable microenvironment for peripheral nerve regeneration. Another pathology responsible for chronic inflammatory pain is osteoarthritis.…”

Section: Exosomesmentioning

confidence: 99%

The Evolution of Current Concept of the Reconstructive Ladder in Plastic Surgery: The Emerging Role of Translational Medicine

De Francesco,

Zingaretti,

Parodi

et al. 2023

Cells

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Plastic surgeons have used the reconstructive ladder for many decades as a standard directory for complex trauma reconstruction with the goal of repairing body structures and restoring functionality. This consists of different surgical maneuvers, such as secondary intention and direct tissue closure, as well as more complex methods such as local tissue transfer and free flap. The reconstructive ladder represents widely known options achievable for tissue reconstruction and wound closure that puts at the bottom rung the simplest methods of reconstruction and strengthens the complexity by moving upward. Regenerative medicine and surgery constitute a quickly spreading area of translational research that can be employed by minimally invasive surgical strategies, with the aim of regenerating cells and tissues in vivo in order to reestablish normal function through the intrinsic potential of cells, in combination with biomaterials and appropriate biochemical stimuli. These translational procedures have the aim of creating an appropriate microenvironment capable of supporting the physiological cellular function to generate the desired cells or tissues and to generate parenchymal, stromal, and vascular components on demand, and above all to produce intelligent materials capable of determining the fate of cells. Smart technologies have been grown that give extra “rungs” on the classic reconstructive ladder to integrate a more holistic, patient-based approach with improved outcomes. This commentary presents the evolution of the traditional concept of the reconstructive ladder in the field of plastic surgery into a new course with the aim of achieving excellent results for soft tissue reconstruction by applying innovative technologies and biologically active molecules for a wide range of surgical diseases.

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Stabilizing the neural barrier – A novel approach in pain therapy

Reinhold

Hartmannsberger

Burek

et al. 2023

Pharmacology & Therapeutics

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Concise review: Current understanding of extracellular vesicles to treat neuropathic pain

Cited by 4 publications

References 119 publications

Contribution of Small Extracellular Vesicles from Schwann Cells and Satellite Glial Cells to Pain Processing

Contribution of Small Extracellular Vesicles from Schwann Cells and Satellite Glial Cells to Pain Processing

The Evolution of Current Concept of the Reconstructive Ladder in Plastic Surgery: The Emerging Role of Translational Medicine

Stabilizing the neural barrier – A novel approach in pain therapy

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