Concise Nanoplatform of Phycocyanin Nanoparticle Loaded with Docetaxel for Synergetic Chemo-sonodynamic Antitumor Therapy

Cao, Jin; Pan, Qiwen; Bei, Shifang; Zheng, Mingxue; Sun, Zhenyan; Qi, Xueyong; Shen, Song

doi:10.1021/acsabm.1c00745

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…The DLS analysis demonstrated a normal distribution of particle sizes, with an average diameter of 175.2 nm, while the TEM image con rmed a consistent spherical shape of the PCNP. These ndings align with previous studies that reported successful synthesis of phycocyanin nanoparticles with similar characteristics (Huang et al 2017;Cao et al 2021). However, it is important to note that the measurements obtained by DLS and TEM may differ due to the different principles underlying each method.…”

Section: Discussionsupporting

confidence: 92%

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Exploring Marine Algae-Derived Phycocyanin Nanoparticles as Safe and Effective Sunscreen Ingredients

Cao

Zheng

et al. 2023

Preprint

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UV radiation poses risks to human skin, including skin cancer. Synthetic chemical sunscreens that protect against UV radiation can have health and environmental concerns. Researchers are studying natural molecules that absorb UV light to find safer alternatives. Marine algae, with unique bioactive substances developed to survive extreme marine conditions, have gained attention as natural photoprotective agents. In this study, phycocyanin nanoparticles (PCNP) were fabricated and characterized using genipin as a crosslinker. PCNP showed a normal particle size distribution, with an average diameter of 175.2 nm. Both PC and PCNP exhibited excellent biocompatibility and did not harm cells. They also demonstrated concentration-dependent antioxidant activity, effectively scavenging free radicals. PCNP had enhanced UV radiation absorption, particularly in the UVB range, likely due to the synergistic effect between PC's internal capacity and the advantages of nanoparticles in the PCNP gel. The PCNP gel showed limited skin permeability, indicating its safety and suitability for topical application, making it a potential candidate as a safe and effective sunscreen ingredient.

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Section: Discussionsupporting

confidence: 92%

“…PC has been found to have potent antioxidant and anti-in ammatory properties, as well as protection against UVB-induced apoptosis. Its ability to absorb light makes it a potential candidate for sunscreens, while its low toxicity pro le makes it safe for cosmetics (Cao et al 2016;Cao et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Exploring Marine Algae-Derived Phycocyanin Nanoparticles as Safe and Effective Sunscreen Ingredients

Cao

Zheng

et al. 2023

Preprint

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“… 41 Moreover, an increase in the speed and accumulation of drug release was found in the ultrasound treatment groups, indicating that ultrasound exposure could aggravate PLGA structural destruction and degradation, consistent with the literature reports and our research results. 8 , 42 , 43 …”

Section: Resultsmentioning

confidence: 99%

One-Step Fabrication of Multifunctional PLGA-HMME-DTX@MnO2 Nanoparticles for Enhanced Chemo-Sonodynamic Antitumor Treatment

Cao¹,

Zheng²,

Sun³

et al. 2022

IJN

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Background Sonodynamic therapy (SDT) and its synergistic cancer therapy derivatives, such as combined chemotherapy-SDT (chemo-SDT), are promising approaches for tumor treatment. However, the main drawbacks restricting their applications are hypoxia in tumors and the reducing microenvironment or high glutathione (GSH) levels. Methods In this study, a hybrid metal MnO 2 was deposited onto nanoparticles fabricated using poly(lactic-co-glycolic acid) (PLGA), carrying docetaxel (DTX) and the sonosensitizer hematoporphyrin monomethyl ether (HMME) (PHD@MnO 2 ) via a one-step flash nanoprecipitation (FNP) method. Characterization and in vitro and in vivo experiments were conducted to explore the chemo-SDT effect of PHD@MnO 2 and evaluate the synergetic antitumor treatment of this nanosystem. Results When low-power ultrasound is applied, the acquired PHD@MnO 2 , whether in solution or in MCF-7 cells, generated ROS more efficiently than other groups without MnO 2 or those treated via monotherapy. Specifically, GSH-depletion was observed when MnO 2 was introduced into the system. PHD@MnO 2 presented good biocompatibility and biosafety in vitro and in vivo. These results indicated that the PHD@MnO 2 nanoparticles overcame hypoxia in tumor tissue and suppressed the expression of hypoxia-inducible factor 1 alpha (HIF-1α), achieving enhanced chemo-SDT. Conclusion This study provides a paradigm that rationally engineered multifunctional metal-hybrid nanoparticles can serve as an effective platform for augmenting the antitumor therapeutic efficiency of chemo-SDT.

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“…Moreover, SDT was found to promote cancer cells’ drug sensitivity by improving cellular internalization of chemotherapeutic drugs, activating the mitochondria-caspase signaling pathway, and down-regulating the expression of ATP-binding cassette transporters ( Ding et al, 2017 ; Xu et al, 2020a ; Ren et al, 2022 ). These functions enhanced the cytotoxicity of chemotherapeutic factors and therefore contributed to the promoted therapeutic efficiency ( An et al, 2020a ; Zhang et al, 2021b ; Cao et al, 2021 ; Zhang et al, 2021c ).…”

Section: Sonodynamic Therapymentioning

confidence: 99%

The crosstalk between sonodynamic therapy and autophagy in cancer

et al. 2022

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As a noninvasive treatment approach for cancer and other diseases, sonodynamic therapy (SDT) has attracted extensive attention due to the deep penetration of ultrasound, good focusing, and selective irradiation sites. However, intrinsic limitations of traditional sonosensitizers hinder the widespread application of SDT. With the development of nanotechnology, nanoparticles as sonosensitizers or as a vehicle to deliver sonosensitizers have been designed and used to target tissues or tumor cells with high specificity and accuracy. Autophagy is a common metabolic alteration in both normal cells and tumor cells. When autophagy happens, a double-membrane autophagosome with sequestrated intracellular components is delivered and fused with lysosomes for degradation. Recycling these cell materials can promote survival under a variety of stress conditions. Numerous studies have revealed that both apoptosis and autophagy occur after SDT. This review summarizes recent progress in autophagy activation by SDT through multiple mechanisms in tumor therapies, drug resistance, and lipid catabolism. A promising tumor therapy, which combines SDT with autophagy inhibition using a nanoparticle delivering system, is presented and investigated.

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Concise Nanoplatform of Phycocyanin Nanoparticle Loaded with Docetaxel for Synergetic Chemo-sonodynamic Antitumor Therapy

Cited by 9 publications

References 32 publications

Exploring Marine Algae-Derived Phycocyanin Nanoparticles as Safe and Effective Sunscreen Ingredients

Exploring Marine Algae-Derived Phycocyanin Nanoparticles as Safe and Effective Sunscreen Ingredients

One-Step Fabrication of Multifunctional PLGA-HMME-DTX@MnO2 Nanoparticles for Enhanced Chemo-Sonodynamic Antitumor Treatment

The crosstalk between sonodynamic therapy and autophagy in cancer

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